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NOVEL ANTIVIRAL COMPOUNDS

The present invention relates to compounds of formula (A), as further defined herein, having antiviral activity, morespecifically HIV (Human Immunodeficiency Virus) replication inhibiting 5 properties. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. The invention further relates to the use of such compounds, optionally combined with one or more other drugs having antiviral activity, for the treatment of animals suffering from viral infections, in particular HIV infection

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl- 2-phenyl-[1,3]dioxolan-2-ylmethyl)lactam methiodides

A series of 1,3-dioxolane-based ligands, having a lactam function were synthesized and tested as potential muscarinic antagonists. The compounds display moderate affinity for the three receptor subtypes M1-M3, with significant selectivity for the M1-M3 over the M2 subtype.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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TREATMENT OF BACTERIAL INDUCED DISEASES USING DNA METHYL TRANSFERASE INHIBITORS

Methods for treating and/or preventing disease conditions caused or induced or aggravated by microbes, especially bacteria, by inhibiting DNA methyltransferase activity, such as by administering to an animal a DNA methyltransferase inhibitor, are disclosed, along with methods of reducing or ablating virulence in bacteria by inhibiting DNA methyltransferase activity.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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Synthetic Route of 5264-35-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, molecular formula is C5H9NO. In a Patent£¬once mentioned of 5264-35-7

N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa

This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing Factor Xa. The present invention is also directed to compositions containing said derivatives, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 5-Methoxy-3,4-dihydro-2H-pyrrole, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, molecular formula is C5H9NO

HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS

The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Simple exploration of 5-Methoxy-3,4-dihydro-2H-pyrrole

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5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, belongs to pyrrolines compound, is a common compound. 5264-35-7In an article, authors is Anderskewitz, Ralf, once mentioned the new application about 5264-35-7.

Pyrrolidinohydroquinazolines – A novel class of CCR3 modulators

A novel class of CCR3 modulators is described. Starting with lead compound 4a (Ki: 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (Ki: 28 nM), which surprisingly proved to be an agonist.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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5264-35-7, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 5264-35-7

PYRROLIDINOHYDROCHINAZOLINES

The invention relates to the novel compounds of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1, E2, X and n are as defined in the description and claims, which are effective modulators of chemokine activity.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, molecular formula is C5H9NO, 5264-35-7. In a Article, authors is Srairi, Driss£¬once mentioned of 5264-35-7

Hydroxylations microbiologiques de pyrrolidinones-2 (note de laboratoire)

Microbial hydroxylations of various pyrrolidin-2 ones, especially N-acylated, with Beauveria sulfurescens have been carried out.The regioselectivity depends on the nature of the substituent on the nitrogen atom and the hydroxylation may occur at position 3,4 or 5 of the heterocycle.Hydroxylations at position 3 or 4 occur with low enantioselectivity.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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NEW APPROACHES TO THE SYNTHESIS OF SPERMINE AND SPERMIDINE ALKALOIDS

New approaches to the formation of macrocyclic lactams are described involving successive ring expansion of 8-lactams and other heterocyclic systems.These methods have been used in the synthesis of a number of spermine and spermidine alkaloids including homaline, celacinnine, dihydroperiphylline, chaenorhine and verbascenine.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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13950-21-5, In an article, published in an article,authors is Capon, Brian, once mentioned the application of 13950-21-5, Name is 1-Methyl-1H-pyrrol-2(5H)-one,molecular formula is C5H7NO, is a conventional compound. this article was the specific content is as follows.

Tautomerism of the Monohydroxy Derivatives of Five-Membered O, N, and S Heterocycles

The O-deuterated enolic tautomers 3-deuteroxybenzofuran, 3-deuteroxybenzothiophene, 3-deuteroxyindole, 3-deuteroxy-1-methylindole, 3-deuteroxyfuran, 3-deuteroxythiophene, 2-deuteroxybenzothiophene, and 2-deuteroxythiophene have been generated in solution in mixtures of CD3COCD3, CD3CN, or CD3SOCD3 with D2O by hydrolysis of their trimethylsilyl derivatives in the presence of DCl (1E-3 – 1E-4 M) and characterized by 1H NMR spectroscopy.Solutions of 3-hydroxypyrrole and of 3-hydroxy-1-methylpyrrole were obtained by methanolysis of their trimethylsilyl derivatives,evaporation of the methanol, and immediate dissolution in DMSO-d6.The carbocyclic analogues of the bicyclic heterocyclic enols 3-deuteroxyindene and 2-deuteroxyindene were also generated in solution.Attempts to prepare solutions of 2-deuteroxyfuran, 2-deuteroxypyrrole, and 2-deuteroxy-1-methylpyrrole were unsuccessful.The kinetics of ketonization of the OH forms of these enols have been investigated in water or aqueous acetonitrile solution.The equilibrium constants for the keto-enol tautomerism were also determined either by direct measurement when sufficient enol was present at equilibrium or as the ratio of the rate constant for enolization of the keto form to that for ketonization of the enol form, the former being determined by the iodine-trapping technique.The effect of solvent on the equilibrium constants was also studied.Sufficient data were available for the equilibrium between 3-hydroxyindole and 3-ketoindole for them to be analyzed by the four-parameter equation of Mills and Beak to yield an a value of 2.4 and a b value of -3.0.The pKas of the bicyclic enols were measured. 3-Hydroxybenzofuran and3-hydroxybenzothiophene are stronger acids than 3-hydroxyindole and 3-hydroxy-1-methylindole.The ketonization reactions are general acid and general base catalyzed and their mechanisms are discussed.

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem