Tag: M.W:0-100

5264-35-7, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole. Here is a downstream synthesis route of the compound 5264-35-7

5264-35-7, EXAMPLE I 5-Amino-2,3-dihydro-1H-indolizin-7-one Monohydrochloride To a solution of lithium diisopropylamide (LDA), prepared from n-BuLi (125 ml, 0.2M) and diisopropylamine (20.24 g, 0.2M), in dry THF (200 ml) was added under N2 at -10¡ã C. 5-methylisoxazole (8.31 g, 0.1 M). The resultant yellow suspension was stirred at -10¡ã C. for 1 hr before 1-aza-2- methoxy-1-cyclopentene (9.9 g, 0.1M) was added dropwise. A light yellow precipitate was immediately formed. The mixture was allowed to warm to ambient over a period of 19 hr. MeOH (100 ml) was slowly added with external cooling so that the internal temperature remained at 25¡ã-26¡ã C. The resulting reddish solution was then stirred at ambient for 24 hr and evaporated in vacuo. Flash column chromatography (30percent MeOH in CH2 Cl2 on silica gel, Em-60) followed by recrystallization (MeOH/Et2 O) gave the desired free base (3 g, 20percent); mp> 230¡ã C. It was then transformed into its HCl salt in MeOH with conc HCl. The salt was further recrystallized from MeOH/Et2 O to yield the title compound; mp>250¡ã C. yield 3 g, 81percent); TLC (30percent MeOH in CH2 Cl2); Rf=0.37; IR (KBr) cm-1, 3500, 3140, 1670, 1590. Anal. Calcd for C8 H10 N2 O. HCl: C, 51.48; H, 5.94; N, 15.01. Found: C, 51.08; H, 5.77; N, 14.89.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 5264-35-7

Reference£º
Patent; Ortho Pharmaceutical Corporation; US4602013; (1986); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.872-32-2, name is 2-Methyl-1-pyrroline. An updated downstream synthesis route of 872-32-2 as follows.

General procedure: Acyl chloride (1.2 mmol, 1.2 equiv) was added to a solution of 4-dimethylaminopyridine (DMAP) (1.2 mmol, 1.2 equiv) in acetonitrile (1.0 mL) at 0 ¡ãC. The reaction was stirred at room temperature for 15 min. A solution of the 5-methyl-3,4-dihydro-2H-pyrrole (1.0 mmol) in acetonitrile (1.0 mL) was added and the reaction was stirred at room temperature for 3 h. p-Toluenesulfonic acid monohydrate (3.0 mmol, 3.0 equiv) was added at 0 ¡ãC under inert atmosphere. The reaction was then stirred at room temperature for 2 h. Arylhydrazine (1.5 mmol, 1.5 equiv) was added and stirred for an addition 5 min at room temperature. The reaction was then heated to 82 ¡ãC for 20 h. The reaction cools down to room temperature. The residue was then dissolved in ethyl acetate and washed with brine and a saturated aqueous solution of NaHCO3. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a crude solid, which was purified by column chromatography on silica gel.

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 2-Methyl-1-pyrroline. We look forward to the emergence of more reaction modes in the future.

Reference£º
Article; Yeo, Se Jeong; Liu, Yongxiang; Wang, Xiang; Tetrahedron; vol. 68; 3; (2012); p. 813 – 818;,
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5264-35-7, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, below Introduce a new synthetic route.

5264-35-7, To 1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethanamine (258 mg, 0.97 mmol) in methanol (5 mL) was added 5-methoxy-3,4-dihydro-2H-pyrrole (96 mg, 0.97 mmol) followed by acetic acid (2 drops). The mixture was heated at 70¡ã C. for 16 hours. The mixture was cooled to room temperature and methanol was removed. Purification by chromatography on silica gel (5percent 7N NH3 in MeOH/CH2Cl2) gave N-(1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethyl)-3,4-dihydro-2H-pyrrol-5-amine (161 mg, 50percent) as an off white solid.1H NMR (300 MHz, CD3OD) delta 1.79-1.90 (m, 2H), 2.41-2.49 (m, 2H), 2.87-2.94 (m, 1H), 3.14-3.21 (m, 1H), 3.34-3.41 (m, 2H), 5.28-5.33 (m, 1H), 7.30-7.47 (m, 4H), 7.77-7.81 (m, 1H), 8.36-8.42 (m, 1H), 8.43 (s, 1H).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5-Methoxy-3,4-dihydro-2H-pyrrole. We look forward to the emergence of more reaction modes in the future.

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Patent; ALLERGAN, INC.; US2010/145061; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.872-32-2, name is 2-Methyl-1-pyrroline. Here is a downstream synthesis route of the compound 872-32-2

872-32-2, General procedure: 2-Methyl-pyrroline (1equiv.) was added to a suspension of an enzyme (20% weight) in a mixture of toluene/water (20mL/100muL), followed by the addition of benzylamine (1equiv.) and isocyanoester 1 (1equiv.). The mixture was stirred at room temperature. The enzyme and water were filtered off through a funnel containing Celite and MgSO4. The solvent was then evaporated in vacuum. The product was purified by column chromatography (silica gel, DCM/methanol).

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 2-Methyl-1-pyrroline, you can also browse my other articles.

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Article; Wilk, Monika; Brodzka, Anna; Koszelewski, Dominik; Madej, Arleta; Paprocki, Daniel; ??d?o-Dobrowolska, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Pyrroline – Wikipedia
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Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, below Introduce a new synthetic route., 5264-35-7

5264-35-7, General procedure: A suspension containing 2,5-dimethyl-1H-pyrrole-3-carbohydrazide (2) (150 mg, 0.979 mmol,1.0 equiv.) and the appropriate methyl lactim (1.96 mmol, 2.0 equiv.) in toluene (2.00 mL, 0.5M) was heated in the microwave reactor at 180 ¡ãC for 1.0 h. The reaction mixture was allowedto cool to room temperature and was then concentrated under diminished pressure. The obtained15residue was applied to a silica gel column (50 g); eluting with 95:5 ? 75:25 DCM-MeOH(containing 10percent NH4OH) afforded the expected triazole.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 5-Methoxy-3,4-dihydro-2H-pyrrole

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Article; Duveau, Damien Y.; Yasgar, Adam; Wang, Yuhong; Hu, Xin; Kouznetsova, Jennifer; Brimacombe, Kyle R.; Jadhav, Ajit; Simeonov, Anton; Thomas, Craig J.; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 630 – 635;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.872-32-2, name is 2-Methyl-1-pyrroline. An updated downstream synthesis route of 872-32-2 as follows.

5-Methyl-3,4-dihydro-2H-pyrrole (60.2 mmol, 1.0 equiv.) was dissolved in CCl4 (100 ml); at 0¡ã C., N-chlorosuccinimide (8.0 equiv.) was added in portions, and the mixture was heated for 72 h at boiling temperature. The reaction mixture was cooled to 0¡ã C., and the resulting solid was filtered out and washed with cooled (0¡ã C.) CCL4 (2.x.50 ml). The filtrate was concentrated to dryness under reduced pressure. Yield: 90percent, 872-32-2

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 872-32-2, you can also browse my other articles.

Reference£º
Patent; Gruenenthal GmbH; US2010/222324; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level. 5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, introduce a new downstream synthesis route., 5264-35-7

To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (1 .98 g; 20 mmol) in methanol (20 mL) was slowly add cyanamide (0.882 g; 21 mmol). After 5 minutes, a suspension appeared and the reaction mixture was stirred at room temperature for 8 days. The volatiles were removed under reduced pressure to afford 2.18 g (100percent) of N-(pyrrolidin-2-ylidene)cyanamide as a white solid which was used without further purification. ESI/APCI(+): 1 10 (M+H). 1 H NMR (DMSO-d6) delta 9.50-8.60 (bs, 1 H, NH); 3.44 (m, 2H, CH2); 2.66 (m, 2H, CH2); 2.02 (m, 2H, CH2).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5264-35-7. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; CHALTIN, Patrick; CHRIST, Frauke; DEBYSER, Zeger; DE MAEYER, Marc; MARCHAND, Arnaud; MARCHAND, Damien; VOET, Arnout; WO2012/65963; (2012); A2;,
Pyrroline – Wikipedia
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An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.541-59-3, name is Maleimide. Here is a downstream synthesis route of the compound 541-59-3. 541-59-3

541-59-3, Ethyl chloroformate (0.38 ml, 4 mmol) was added dropwise to a stirred solution maleimide (0.3 g, 3 mmol) and triethylamine (0.5 ml, 3.5 mmol) in dimethylformamide (2 ml) at 0-5 C. The reaction mixture was allowed to warm to room temperature and stand for 4 h. Methyl alcohol (1 ml) was added, diluted with chloroform (20 ml) and washed with water (3*10 ml). The chloroform solution was dried (Na2SO4) and concentrated in vacuum. The residue was purified in chloroform and hexane on a silica gel column to give N-ethoxycarbonyl-maleimide (yield 41%). 1H NMR (CDCl3) delta 1.34 (3H, t, CH3), 4.27 (2H, q, CH2), 6.21 (1H, d, CH=), 6.72 (1H, d, CH=).

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 541-59-3

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Patent; Thermo Fisher Scientific Baltics UAB; Lagunavicius, Arunas; Tauraite, Daiva; Barkauskaite, Jurgita; Grinius, Leonas; (31 pag.)US9273304; (2016); B2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole. Here is a downstream synthesis route of the compound 5264-35-7

5264-35-7, Step 1 To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (1.98 g; 20 mmol) in methanol (20 mL) was slowly add cyanamide (0.882 g; 21 mmol). After 5 minutes, a suspension appeared and the reaction mixture was stirred at room temperature for 8 days. The volatiles were removed under reduced pressure to afford 2.18 g (100percent) of N-(pyrrolidin-2-ylidene)cyanamide as a white solid which was used without further purification. ESI/APCI(+): 110 (M+H). 1H NMR (DMSO-d6) delta 9.50-8.60 (bs, 1H, NH); 3.44 (m, 2H, CH2); 2.66 (m, 2H, CH2); 2.02 (m, 2H, CH2).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5-Methoxy-3,4-dihydro-2H-pyrrole. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; Katholieke Universiteit Leuven; Chaltin, Patrick; Christ, Frauke; Debyser, Zeger; De Maeyer, Marc; Marchand, Arnaud; Marchand, Damien; Voet, Arnout; US2013/245049; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole. An updated downstream synthesis route of 5264-35-7 as follows.

5-methoxy-3,4-dihydro-2H-pyrrole (0.3 mL) was added to the solution of 5-propyl-8- [(4-methylpiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole tetraTFA salt (110 mg, 138 mg) in methanol (1 mL) at room temperature. The EPO mixture was stirred at room temperature overnight and purified by preparative HPLC (10-70percent CH3CN) to afford the title compound as its TFA salt (31mg). MS (M+l): 407.1. 1H NMR (400 MHz, CD3OD) delta ppm 0.91 (t, J=7.42 Hz, 3 H), 0.99 (d, J=6.44 Hz, 3 H), 1.06 – 1.28 (m, 2 H), 1.55 – 1.89 (m, 5 H), 2.14 – 2.39 (m, 2 H), 2.89 (s, 1 H), 3.00 – 3.21 (m, 4 H), 3.67 – 3.92 (m, 3 H), 3.94 – 4.06 (m, 2 H), 4.08 – 4.18 (m, 2 H), 4.60 (s, 1 H), 4.79 – 4.89 (m, 2 H), 7.17 – 7.27 (m, 1 H), 7.41 – 7.60 (m, 2 H)., 5264-35-7

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 5-Methoxy-3,4-dihydro-2H-pyrrole, you can also browse my other articles.

Reference£º
Patent; AstraZeneca AB; WO2006/101434; (2006); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem