Tag: M.W:0-100

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

872-32-2, General procedure: 2-Methyl-pyrroline (1equiv.) was added to a suspension of an enzyme (20% weight) in a mixture of toluene/water (20mL/100muL), followed by the addition of benzylamine (1equiv.) and isocyanoester 1 (1equiv.). The mixture was stirred at room temperature. The enzyme and water were filtered off through a funnel containing Celite and MgSO4. The solvent was then evaporated in vacuum. The product was purified by column chromatography (silica gel, DCM/methanol).

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Wilk, Monika; Brodzka, Anna; Koszelewski, Dominik; Madej, Arleta; Paprocki, Daniel; ??d?o-Dobrowolska, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1B (2.1 g, 10 mmol), 194 5-methoxy-3,4-dihydro-2H-pyrrole (1.49 g, 15 mmol) and 4 cetic acid (5 drops) in 170 methanol (12 mL) was heated by microwave at 100 C. for 2 hours. The mixture was concentrated and the residue was purified by column chromatography on silica gel (EtOAc/Pet. Ether, 1/4 to 4/1, v/v) to give 76A (2 g, 76% yield) as a white 195solid: ESI m/z 266.9, 264.9 [M+H]+ ., 5264-35-7

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Seal Rock Therapeutics, Inc.; BROWN, Samuel David; US2018/291002; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.,5264-35-7

To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (1 .98 g; 20 mmol) in methanol (20 mL) was slowly add cyanamide (0.882 g; 21 mmol). After 5 minutes, a suspension appeared and the reaction mixture was stirred at room temperature for 8 days. The volatiles were removed under reduced pressure to afford 2.18 g (100percent) of N-(pyrrolidin-2-ylidene)cyanamide as a white solid which was used without further purification. ESI/APCI(+): 1 10 (M+H). 1 H NMR (DMSO-d6) delta 9.50-8.60 (bs, 1 H, NH); 3.44 (m, 2H, CH2); 2.66 (m, 2H, CH2); 2.02 (m, 2H, CH2).

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; CHALTIN, Patrick; CHRIST, Frauke; DEBYSER, Zeger; DE MAEYER, Marc; MARCHAND, Arnaud; MARCHAND, Damien; VOET, Arnout; WO2012/65963; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.

872-32-2, General procedure: 2-Methyl-pyrroline (1equiv.) was added to a suspension of an enzyme (20% weight) in a mixture of toluene/water (20mL/100muL), followed by the addition of benzylamine (1equiv.) and isocyanoester 1 (1equiv.). The mixture was stirred at room temperature. The enzyme and water were filtered off through a funnel containing Celite and MgSO4. The solvent was then evaporated in vacuum. The product was purified by column chromatography (silica gel, DCM/methanol).

872-32-2 2-Methyl-1-pyrroline 70103, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Wilk, Monika; Brodzka, Anna; Koszelewski, Dominik; Madej, Arleta; Paprocki, Daniel; ??d?o-Dobrowolska, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.,872-32-2

General procedure: 2-Methyl-pyrroline (1equiv.) was added to a suspension of an enzyme (20% weight) in a mixture of toluene/water (20mL/100muL), followed by the addition of benzylamine (1equiv.) and isocyanoester 1 (1equiv.). The mixture was stirred at room temperature. The enzyme and water were filtered off through a funnel containing Celite and MgSO4. The solvent was then evaporated in vacuum. The product was purified by column chromatography (silica gel, DCM/methanol).

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Wilk, Monika; Brodzka, Anna; Koszelewski, Dominik; Madej, Arleta; Paprocki, Daniel; ??d?o-Dobrowolska, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

5264-35-7, EXAMPLE I 5-Amino-2,3-dihydro-1H-indolizin-7-one Monohydrochloride To a solution of lithium diisopropylamide (LDA), prepared from n-BuLi (125 ml, 0.2M) and diisopropylamine (20.24 g, 0.2M), in dry THF (200 ml) was added under N2 at -10¡ã C. 5-methylisoxazole (8.31 g, 0.1 M). The resultant yellow suspension was stirred at -10¡ã C. for 1 hr before 1-aza-2- methoxy-1-cyclopentene (9.9 g, 0.1M) was added dropwise. A light yellow precipitate was immediately formed. The mixture was allowed to warm to ambient over a period of 19 hr. MeOH (100 ml) was slowly added with external cooling so that the internal temperature remained at 25¡ã-26¡ã C. The resulting reddish solution was then stirred at ambient for 24 hr and evaporated in vacuo. Flash column chromatography (30percent MeOH in CH2 Cl2 on silica gel, Em-60) followed by recrystallization (MeOH/Et2 O) gave the desired free base (3 g, 20percent); mp> 230¡ã C. It was then transformed into its HCl salt in MeOH with conc HCl. The salt was further recrystallized from MeOH/Et2 O to yield the title compound; mp>250¡ã C. yield 3 g, 81percent); TLC (30percent MeOH in CH2 Cl2); Rf=0.37; IR (KBr) cm-1, 3500, 3140, 1670, 1590. Anal. Calcd for C8 H10 N2 O. HCl: C, 51.48; H, 5.94; N, 15.01. Found: C, 51.08; H, 5.77; N, 14.89.

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ortho Pharmaceutical Corporation; US4602013; (1986); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.

872-32-2, A solution of 5-methyl-3,4-dihydro-2H-pyrrole (83 mg, 1.0 mmol), allyl chloride (114 mg, 1.5 mmol), Pd(AcO)2 (4 mg, 0.02 mmol), PPh3 (21 mg, 0.08 mmol), and Et3N (202 mg, 2.0 mmol) in THF (15 mL) was placed in a 45 mL autoclave. The autoclave was purged, pressurized (400 psi CO) and then heated at 100 ¡ãC, under magnetic stirring, for 4 h. After this time, the solution was cooled to room temperature and the solvent was removed under reduced pressure to give a crude material. The crude mixture was then purified by flash chromatography (silica gel, partly deactivated with triethylamine, eluent petroleum ether/ethyl acetate 70:30) to afford the pure beta-lactam 2 as a pale yellow oil (121 mg, 80percent). 1H NMR (400.13 MHz, CDCl3): delta 2.23 (3H, s, CH3), 2.44-2.56 (2H, m, CH2CH2CH2), 3.04-3.15 (2H, m, CH2CH2CH2N), 3.79-3.92 (2H, m, CH2N), 4.81 (1H, d, J=6.0 Hz, CHC=O), 5.13-5.20 (2H, m, CH=CH2), 5.94-6.02 (1H, m, CH=CH2) ppm. 13C NMR (100.62 MHz, CDCl3): delta 16.4 (2C, CH3 and CH2CH2CH2), 27.2, 41.1, 48.1, 74.1, 117.8, 131.3, 168.8 ppm. FT-IR (CHCl3): nu=3083, 2981, 2929, 2866, 1670, 1632, 1416 cm-1. GC-MS (70 eV): m/z (percent)=151 (33) [M]+, 110 (9), 83 (80), 82 (100), 68 (20). HRMS (ESI): calcd for C9H14NO [M+H]+ 152.1076; found 152.1078.

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Perrone, Serena; Cannazza, Giuseppe; Caroli, Antonio; Salomone, Antonio; Troisi, Luigino; Tetrahedron; vol. 70; 39; (2014); p. 6938 – 6943;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.

n-Butyllithium (53.0 mL, 133 mmol, 2.5 M solution in hexanes) was added dropwise to a stirred solution of diisopropylamine (18.6 mL, 133 mmol) in THF (120 mL) at 0 C. After 5 min, the solution was cooled to -78 C and a solution of 2-methyl-1-pyrroline (11.4 mL, 120 mmol) in THF (120 mL) was added dropwise. The reaction mixture was stirred at -78 C for 2 h. A solution of 1-bromo-3-chloropropane (12.5 mL, 126 mmol) in THF (120 mL) was then added dropwise and the mixture was stirred at RT for 16 h. The mixture was poured into 0.5 M aq. NaOH solution (450 mL), the product extracted into ether (3 * 500 mL), and the combined organic extracts were dried over K2CO3, filtered and concentrated in vacuo to afford 2,3,5,6,7,8-hexahydro-1H-indolizin-4-ium chloride as a yellow-orange solid (18.0 g, 94%). Rf 0.65 (100:10:1 CHCl3:MeOH:aq. NH3 (18 M)); numax (thin film)/cm-1 3396w, 2950s, 2867 m, 1644s, 1431 m, 1303 m, 1015w; deltaH (400 MHz, C6D6) 1.38 – 1.61 (6 H, m), 1.89 – 2.00 (4 H, m), 3.12 (2 H, t, J 6.5), 3.73 (2 H, app. tquin, J 7.5, 5.5, 2.0); deltaC (100 MHz, C6D6) 22.8, 23.7, 32.5, 32.7, 37.3, 44.8, 61.3, 175.5; m/z (ESI+) 162 (M(37Cl)H+, 32%), 160 (M(35Cl)H+, 100), 124 ((M – Cl)+, 35). To a stirred solution of the iminium salt (9.00 g, 56.4 mmol) in water (900 mL) was added powdered NaOH (56.4 g, 1.41 mol) and the reaction mixture was stirred at RT for 16 h. Pentane (900 mL) was added and the mixture was stirred at RT for 1 h. The separated organic layer was dried over K2CO3, filtered and concentrated in vacuo to afford the title compound as a colourless oil (5.15 g, 74%). numax (thin film)/cm-1 2930s, 1683 m, 1648w, 1445w, 1280m, 1185 m; deltaH (400 MHz, C6D6) 1.47 – 1.56 (2 H, m), 1.81 – 1.88 (2 H, m), 2.12 – 2.18 (2 H, m), 2.24 – 2.31 (2 H, m), 2.66 (2 H, t, J 6.5), 2.80 (2 H, t, J 5.5), 4.43 (1 H, tt, J 3.5, 1.5); deltaC (100 MHz, C6D6) 21.9, 22.4, 23.5, 29.2, 47.1, 53.1, 88.2 (4 carbon not observed); m/z (ESI+) 124 (MH+, 100%)., 872-32-2

872-32-2 2-Methyl-1-pyrroline 70103, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Seah, Kang Yee; Robertson, Jeremy; Tetrahedron; vol. 75; 46; (2019);,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5264-35-7

a) The corresponding Grignard compound is prepared from 22.6 g of 4-bromobiphenyl with 2.36 g of magnesium in 75 ml of THF. A solution of 8.0 g of 5-methoxy-2H-3,4-dihydropyrrole in 25 ml of THF is added dropwise to this solution. The mixture is boiled at reflux for 5 hrs., then poured into a saturated solution of ammonium chloride, extracted with ethyl acetate, dried and concentrated. The residue is recrystallized from isopropanol, with 1.93 g of 5-biphenylyl-2H-3,4-dihydropyrrole being isolated, m.p. 230¡ã C.

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; Hoffmann-La Roche Inc.; US6034275; (2000); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

5264-35-7, General procedure: A suspension containing 2,5-dimethyl-1H-pyrrole-3-carbohydrazide (2) (150 mg, 0.979 mmol,1.0 equiv.) and the appropriate methyl lactim (1.96 mmol, 2.0 equiv.) in toluene (2.00 mL, 0.5M) was heated in the microwave reactor at 180 ¡ãC for 1.0 h. The reaction mixture was allowedto cool to room temperature and was then concentrated under diminished pressure. The obtained15residue was applied to a silica gel column (50 g); eluting with 95:5 ? 75:25 DCM-MeOH(containing 10percent NH4OH) afforded the expected triazole.

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Article; Duveau, Damien Y.; Yasgar, Adam; Wang, Yuhong; Hu, Xin; Kouznetsova, Jennifer; Brimacombe, Kyle R.; Jadhav, Ajit; Simeonov, Anton; Thomas, Craig J.; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 630 – 635;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem