Tag: M.W:100-200

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Intensified crystallization in complex media: Heuristics for crystallization of platform chemicals, published in 2012, which mentions a compound: 58081-05-3, mainly applied to crystallization heuristic complex media platform chem, Formula: C4H6O3.

This paper presents heuristics for the integration of fermentation with the appropriate crystallization based in-situ product recovery (ISPR) technique. Here techniques, such as co-crystallization (CC), evaporative crystallization (EC), template induced crystallization (TIC), cooling crystallization (ClC) and electrochem. induced crystallization (EIC), that were recently developed or applied to fermentations were evaluated. For this purpose, the operating windows of fermentation and crystallization of the top-twelve platform chems. as identified by the US Department of Energy were extracted from literature and processed. The results show that in principle all mols. can be crystallized and confirm that different classes of platform chems. require different crystallization techniques. Finally, the results show that intensified crystallization, by means of utilizing external fields (EIC) or tunable solid state properties (CC), seems to be a very feasible ISPR technique.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron called Enantiomerically pure β,γ-epoxyesters from β-hydroxylactones: synthesis of β-hydroxyesters and (-)-GABOB, Author is Larcheveque, M.; Henrot, S., which mentions a compound: 58081-05-3, SMILESS is O=C1OC[C@H](O)C1, Molecular C4H6O3, HPLC of Formula: 58081-05-3.

The preparation of enantiomerically pure β,γ-epoxy esters was achieved by chemoselective opening of β-hydroxybutanolides with Me3SiI followed by cyclization of the resulting iodohydrins with Ag2O. The reaction of these epoxy esters with lithio- or magnesiocuprates afforded stereochemically pure α-substituted-β-hydroxy esters. Alternatively, the title compound, (R)-H2NCH2CH(OH)CH2CO2H, was synthesized in optically pure form from the iodohydrin (R)-ICH2CH(OH)CH2CO2Et.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one(SMILESS: O=C1OC[C@H](O)C1,cas:58081-05-3) is researched.HPLC of Formula: 58081-05-3. The article 《Synthesis of (S)-N-(benzyloxy)-4-(acetoxymethyl)-2-azetidinone, a potential intermediate for carbapenem antibiotics, by a chemomicrobiological approach》 in relation to this compound, is published in Heterocycles. Let’s take a look at the latest research on this compound (cas:58081-05-3).

(R)-Me3COCH2CH(OH)CH2CO2Et, which was prepared by Bakers’ yeast reduction of Me3COCH2COCH2CO2Et, was converted to (R)-3-hydroxybutyrolactone. After cleavage of the lactone ring with PhCH2ONH2, β-lactam cyclization of the hydroxamate was carried out by the Mitsunobu procedure with complete inversion of configuration at C-3 to give (S)-N-benzyloxy-4-acetoxymethyl-2-azetidinone (I). The (R)-azetidinone was also synthesized from (S)-malic acid via (S)-3-hydroxybutyrolactone.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Yang; Xia, Yihong; Lai, Yongji; Tang, Fang; Luo, Zengwei; Xue, Yongbo; Yao, Guangmin; Zhang, Yonghui; Zhang, Jinwen researched the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ).Reference of (R)-4-Hydroxydihydrofuran-2(3H)-one.They published the article 《Efficient synthesis of kinsenoside and goodyeroside A by a chemo-enzymatic approach》 about this compound( cas:58081-05-3 ) in Molecules. Keywords: kinsenoside chemoenzymic synthesis; goodyeroside chemoenzymic synthesis. We’ll tell you more about this compound (cas:58081-05-3).

Kinsenoside (1) and goodyeroside A (2), two naturally occurring stereoisomers with diverse biol. activities, have been synthesized efficiently by a chemo-enzymic approach with a total yield of 12.7%. The aglycons, (R)- and (S)-3-hydroxy-γ-butyrolactone, were prepared from d- and l-malic acid by a four-step chem. approach with a yield of 75%, resp. These butyrolactones were then successfully glycosidated using β-D-glucosidase as a catalyst in a homogeneous organic-water system. Under the optimized enzymic conditions, the yields of kinsenoside and goodyeroside A in the enzymic steps both reached 16.8%.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Recommanded Product: 58081-05-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Chiroptical properties of lactones. II. Electronic rotatory strengths of the n .far. π* transition in saturated γ- and δ-lactones. Author is Richardson, Frederick S.; Pitts, William.

The chiroptical properties associated with the n→π* transition of dissymmetric saturated γ- and δ-lactones were calculated and relations between the chiroptical observables and the stereochem. and electronic structural features were examined The calculations were based on the INDO MO method for the electronic structure of the mol. systems and excited states were constructed in the virtual orbital-CI approximation The highest and second highest occupied orbitals calculated for each of the 17 structures studied are, resp., the inplane n and the out-of-plane π° nonbonding orbitals localized on the O:CO group. The lowest lying singlet state is nπ* and the calculated transition wavelengths for transitions in this state are 197-230 nm. The calculated n→π* rotatory strengths and dissymmetry factors agree with experiment

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one(SMILESS: O=C1OC[C@H](O)C1,cas:58081-05-3) is researched.Recommanded Product: 58081-05-3. The article 《A Concise Stereoselective Total Synthesis of Methoxyl Citreochlorols and Their Structural Revisions》 in relation to this compound, is published in European Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:58081-05-3).

A concise, stereoselective and protecting group free approaches for the total synthesis of (-)-(2S,4R)- and (+)-(2R,4S)-3′-methoxyl citreochlorols, e.g., I, and their stereoisomers are demonstrated. All four stereoisomers were synthesized to establish the absolute stereochem. of the reported structures and the structures were revised accordingly. The approach involves chelation controlled regioselective reduction of a diester, silyl iodide promoted ring-opening iodo esterification of lactones, highly chemo- and regioselective ring-opening of an epoxy ester, dichloromethylation of a carboxyl group, and syn- and anti-selective reduction of the resulted β-hydroxy ketone as key steps.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Synthesis of 11-C-20-C segment of leukotriene B4 and migration of silyl protecting group. Author is Wang, Yanfang; Li, Jincui; Wu, Yulin.

A new synthesis of 11-C-20-C segment of leukotriene B4, 2(R)-hydroxydec-4(Z)-enal derivatives I (R = SiPh2CMe3, SiMe2CMe3, CPh3) using ascorbic acid as chiron is described. A partial or full migration of silyl protecting group from a secondary hydroxy group to a vicinal primary one is discovered in the Wittig reaction of hemiacetals II (R1 = SiPh2CMe3, SiMe2CMe3) with Me(CH2)5P+Ph3Br-.

Although many compounds look similar to this compound(58081-05-3)Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one, numerous studies have shown that this compound(SMILES:O=C1OC[C@H](O)C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Structure determination and synthesis of a new cerebroside isolated from the traditional Chinese medicine Typhonium giganteum Engl., published in 2002-05-06, which mentions a compound: 58081-05-3, mainly applied to cerebroside Typhonium structure; medicinal plant typhoniside structure, Category: pyrrolines.

A new cerebroside, typhoniside A (I), with C18-4,8-sphingadienine as the long-chain base, has been isolated from the traditional Chinese medicine Typhonium giganteum Engl., and its structure was determined by 2D-NMR and MS methods. It was then synthesized using D-xylose and ascorbic acid as the chiral starting materials.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Total Synthesis of (+)-Mycotrienol and (+)-Mycotrienin I: Application of Asymmetric Crotylsilane Bond Constructions, published in 1998-05-06, which mentions a compound: 58081-05-3, mainly applied to mycotrienol mycotrienin I synthesis, Recommanded Product: 58081-05-3.

A highly convergent asym. synthesis of the ansamycin antibiotics (+)-mycotrienin I (I) [R = 2-(S)-cyclohexylcarbonylaminopropionyl] and (+)-mycotrienol I (R = H) has been achieved through the synthesis and coupling of the C9-C16 subunit II and the aromatic subunit III, resp. This article describes the complete details of that work as it illustrates the utility of our developing chiral (E)-crotylsilane bond construction methodol. in total synthesis. All four stereogenic centers were introduced using chiral allylsilane bond construction methodol. In the synthesis of subunit II, the C12 and C13 stereocenters were installed using an asym. crotylsilylation reaction to α-keto dibenzyl acetal MeCOCH(OCH2Ph)2. The C11 stereocenter was subsequently installed via a chelate-controlled addition of allyltrimethylsilane to establish the anti-1,3-diol system. The C14-C15 trisubstituted double bond was then installed via a reductive opening of α,β-unsaturated lactone (IV). Aromatic subunit III was chosen on the basis of its synthon equivalency to the amidobenzoquinone system of I. Subunit III was constructed in a concise six-step sequence which incorporates the C3 stereogenic center of the C1-C5 side chain. The C3 stereogenic center was established using a Weinreb amidation of 2,5-dimethoxy-3-phenylsulfonylmethylaniline with (+)-3R-methoxybutanolide, whose absolute stereochem. was derived using the crotylsilane methodol. The union of subunit II with aromatic subunit III was accomplished using a sulfone-based coupling strategy. Coupling product (V) was transformed through a sequence of steps to triene. Divergence from this advanced intermediate allows access to both natural products. The successful completion of the synthesis included the incorporation of the (E,E,E)-triene unit with simultaneous macrocyclization through a palladium (0)-catalyzed (Stille-type) coupling macrocyclization.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Synthesis and Nonenzymic Template-Directed Polymerization of 2′-Amino-2′-deoxythreose Nucleotides, the main research direction is polymerization aminodeoxythreose nucleotide synthesis RNA DNA duplex TNA threose.Quality Control of (R)-4-Hydroxydihydrofuran-2(3H)-one.

Threose nucleic acid (TNA) is a potential alternative genetic material that may have played a role in the early evolution of life. We have developed a novel synthesis of 2′-amino modified TNA nucleosides (2′-NH2-TNA) based on a cycloaddition reaction between a glycal and an azodicarboxylate, followed by direct nucleosidation of the cycloadduct. Using this route, we synthesized the thymine and guanine 2′-NH2-TNA nucleosides in seven steps with 24% and 12% overall yield, resp. We then phosphorylated the guanine nucleoside on the 3′-hydroxyl, activated the phosphate as the 2-methylimidazolide, and tested the ability of the activated nucleotide to copy C4 RNA, DNA, and TNA templates by nonenzymic primer extension. We measured pseudo-first-order rate constants for the first nucleotide addition step of 1.5, 0.97, and 0.57 h-1 on RNA, DNA, and TNA templates, resp., at pH 7.5 and 4 °C with 150 mM NaCl, 100 mM N-(hydroxylethyl)-imidazole catalyst, and 5 mM activated nucleotide. The activated nucleotide hydrolyzed with a rate constant of 0.39 h-1, causing the polymerization reaction to stall before complete template copying could be achieved. These extension rates are more than 1 order of magnitude slower than those for amino-sugar ribonucleotides under the same conditions, and copying of the TNA template, which best represented a true self-copying reaction, was the slowest of all. The poor kinetics of 2′-NH2-TNA template copying could give insight into why TNA was ultimately not used as a genetic material by biol. systems.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem