Tag: M.W:100-200

Reference of 256-96-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 256-96-2, Name is 5H-Dibenzo[b,f]azepine, SMILES is C12=CC=CC=C1C=CC3=CC=CC=C3N2, belongs to pyrrolines compound. In a article, author is Lee, Sun Young, introduce new discover of the category.

Evaluation of Aging Behavior of Nitrile Butadiene Rubbers via Oxygen-consumption Experiments

The aging behavior of nitrile butadiene rubber (NBR) was studied by performing a thermo-oxidatively accelerated-aging test in a closed oxygen-rich atmosphere. The oxygen-consumption rates of the aged NBR were measured and correlated with changes in the chemical and physical properties of the rubber. Changes in the morphological, chemical, and mechanical properties of the aged NBR were examined via scanning electron microscopy, X-ray photoelectron spectroscopy (XPS), and tensile tests. Morphological observations revealed that the aging conditions severely degraded the surface of the NBR, and additive particles migrated from the inner part of the NBR to the surface at temperatures above 60 degrees C. XPS indicated that the surface or cross-sectional face of the NBR was oxidized heterogeneously after the thermo-oxidative aging. The oxidation induced cross-linking, which caused the tensile modulus of the NBR to increase with an increase in the aging time and temperature; tensile elongation tended to decrease. The results of the thermo-oxidative accelerated-aging test were analyzed based on the Arrhenius model, using data of the oxygen-consumption rates. Finally, the activation energy of the degradation process was determined and the lifetime of the NBR was calculated. The lifetime of NBR conserved at 25 degrees C was estimated to be 11.12 years at a 40 % oxygen-consumption rate.

Reference of 256-96-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 256-96-2.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Electric Literature of 57-71-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 57-71-6, Name is Diacetyl Monoxime, SMILES is C/C(C(C)=O)=NO, belongs to pyrrolines compound. In a article, author is Ludwig, Jannis, introduce new discover of the category.

Synthesis of 4-substituted azopyridine-functionalized Ni(II)-porphyrins as molecular spin switches

We present the synthesis and the spin switching efficiencies of Ni(II)-porphyrins substituted with azopyridines as covalently attached photoswitchable ligands. The molecules are designed in such a way that the azopyridines coordinate to the Ni ion if the azo unit is in cis configuration. For steric reasons no intramolecular coordination is possible if the azopyridine unit adopts the trans configuration. Photoisomerization of the azo unit between cis and trans is achieved upon irradiation with 505 nm (trans -> cis) and 435 nm (cis -> trans). Concurrently with the isomerization and coordination/decoordination, the spin state of the Ni ion switches between singlet (low-spin) and triplet (high-spin). Previous studies have shown that the spin switching efficiency is strongly dependent on the solvent and on the substituent at the 4-position of the pyridine unit. We now introduced thiol, disulfide, thioethers, nitrile and carboxylic acid groups and investigated their spin switching efficiency.

Electric Literature of 57-71-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 57-71-6.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

In an article, author is Gao, Xinshuai, once mentioned the application of 95-14-7, Category: pyrrolines, Name is 1H-Benzo[d][1,2,3]triazole, molecular formula is C6H5N3, molecular weight is 119.12, MDL number is MFCD00005699, category is pyrrolines. Now introduce a scientific discovery about this category.

Preparation of Amorphous Poly(aryl ether nitrile ketone) and Its Composites with Nano Hydroxyapatite for 3D Artificial Bone Printing

PEEK had been used to fabricate artificial bones by 3D printing widely, but it expressed unsatisfactory interlayer performance of 3D printing and weak compatibility with nano hydroxyapatite(nHA) due to the limits of molecular structures. Here an amorphous poly(aryl ether ketone) for 3D bone printing, PEK-CN, was designed and synthesized via nucleophilic substitution from 4,4′-difluorobenzophenone, phenolphthalein and 2,6-dichlorobenzonitrile, which possessed much stronger interlayer strength due to van der Waals force between polar groups(-CNs). Specifically, the stronger interlayer strength resulted in lower porosity(3% with 100% infill rate) and more comparable mechanical properties(the maximum tensile strength was similar to 110 MPa) to cortical bone. Importantly, PEK-CN had passed in vitro cytotoxicity testing and samples of human mandible and maxillary bones based on PEKCN were printed by fused deposition modeling(FDM) successfully. Moreover, PEK-CN/nHA composites were obtained to enhance bioactivity of resin, and PEK-CN without limits of crystal lattices expressed excellent compatibility with nano hydroxyapatite. Our work provided a high performance resin for 3D bone printing, which would bring better solutions for artificial bone materials.

If you are interested in 95-14-7, you can contact me at any time and look forward to more communication. Category: pyrrolines.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: pyrrolines, 525-76-8, Name is 2-Methyl-4H-benzo[d][1,3]oxazin-4-one, molecular formula is C9H7NO2, belongs to pyrrolines compound. In a document, author is Ricko, Sebastijan, introduce the new discover.

Double Spirocyclization of Arylidene-Delta(2)-Pyrrolin-4-Ones with 3-Isothiocyanato Oxindoles

Arylidene-Delta(2)-pyrrolin-4-ones undergo organocatalyzed double spirocyclization with 3-isothiocianato oxindoles in a domino 1,4/1,2-addition sequence. The products contain three contiguous stereocenters (ee up to 98%, dr up to 99:1, 12 examples). The absolute configuration of the major diastereomer was determined by single crystal X-ray analysis. Along with heterocyclic Michael acceptors based on oxazolone, isoxazolone, thiazolidinone, pyrazolone, and pyrimidinedione, the reported results display the applicability of unsaturated Delta(2)-pyrrolin-4-ones (pyrrolones) for the organocatalyzed construction of 3D-rich pyrrolone-containing heterocycles.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 525-76-8. Category: pyrrolines.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

In an article, author is Chen, Mengyuan, once mentioned the application of 95-45-4, Name is Dimethylglyoxime, molecular formula is C4H8N2O2, molecular weight is 116.1185, MDL number is MFCD00002117, category is pyrrolines. Now introduce a scientific discovery about this category, Safety of Dimethylglyoxime.

Z-Selective alpha-Arylation of alpha,beta-Unsaturated Nitriles via [3,3]-Sigmatropic Rearrangement

The Morita-Baylis-Hillman (MBH) reaction and [3, 3]-sigmatropic rearrangement are two paradigms in organic synthesis. We have merged the two types of reactions to achieve [3,3]-rearrangement of aryl sulfoxides with alpha,beta-unsaturated nitriles. The reaction was achieved by sequentially treating both coupling partners with electrophilic activator (Tf2O) and base, offering an effective approach to prepare synthetically versatile alpha-aryl alpha,beta-unsaturated nitriles with Z-selectivity through direct alpha-C-H arylation of unmodified alpha,beta-unsaturated nitriles. The control experiments and DFT calculations support a four-stage reaction sequence, including the assembly of Tf2O activated aryl sulfoxide with alpha,beta-unsaturated nitrile, MBH-like Lewis base addition, [3,3]-rearrangement, and E1cB-elimination. Among these stages, the Lewis base addition is diastereoselective and E1cB-elimination is cis-selective, which could account for the remarkable Z-selectivity of the reaction.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 611-64-3, Name is 9-Methylacridine, molecular formula is C14H11N, belongs to pyrrolines compound. In a document, author is Roth, Steven D., introduce the new discover, Category: pyrrolines.

Intermolecularly hydrogen-bonded dimeric helices: tripyrrindiones

A rare and unusual class of tripyrrolic compounds, violet-colored tripyrrin-1,14-diones, can be prepared easily and in moderately high yields from base (piperidine)-catalyzed condensation of 3-pyrrolin-2-ones with 2,5-diformylpyrroles. Dipyrrinones adopt the all-syn-Z conformation leading to helical, lock-washer like structures, which form dimers that are held together by intermolecular hydrogen bonds in nonpolar solvents and in the crystal. Strong bathochromic spectral shifts of the tripyrrindione similar to 480 nm long wavelength UV-visible absorption band are seen with added base: DBU, 615 nm; TFA, 573 nm; and Zn(OAc)(2), 586 nm. (c) 2007 Elsevier Ltd. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 611-64-3. Category: pyrrolines.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Chemistry is an experimental science, Application In Synthesis of 4-(Methylthio)benzaldehyde, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 3446-89-7, Name is 4-(Methylthio)benzaldehyde, molecular formula is C8H8OS, belongs to pyrrolines compound. In a document, author is Nihmath, A..

Hydroxyapatite as a Potential Nanofiller in Technologically Useful Chlorinated Acrylonitrile Butadiene Rubber

This paper investigates the effect of hydroxyapatite nanoparticles (HA) on the cure characteristics, tensile and tear strength, elongation at break, hardness, abrasion resistance, heat build-up, resilience, glass transition temperature, oil resistance, alternating current (AC) conductivity and transport properties of chlorinated nitrile rubber (Cl-NBR). The maximum and minimum torque values were increased whereas the cure time values were decreased with the HA content in the Cl-NBR. The uniform dispersion of HA in Cl-NBR was obtained from scanning electron microscopy (SEM) and X-ray diffraction (XRD). Differential scanning calorimetry (DSC) showed the increased glass transition temperature of Cl-NBR with the addition of HA particles. Mechanical properties, conductivity and oil resistance of the composites were greatly increased with the loading of hydroxyapatite. Diffusion results were explained in terms of the loading of nanoparticles and size of the penetrant molecules. Arrhenius and thermodynamic parameters for the diffusion process have been estimated and an anomalous diffusion mechanism was observed.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 3446-89-7. Application In Synthesis of 4-(Methylthio)benzaldehyde.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: pyrrolines, 5306-85-4, Name is (3R,3aR,6S,6aR)-3,6-Dimethoxyhexahydrofuro[3,2-b]furan, molecular formula is C8H14O4, belongs to pyrrolines compound. In a document, author is BUNN, SJ, introduce the new discover.

STAUROSPORINE INHIBITS INOSITOL PHOSPHATE FORMATION IN BOVINE ADRENAL-MEDULLARY CELLS

The effect of protein kinase C activators and inhibitors on histamine-stimulated phospholipase C in bovine adrenal medullary cells has been investigated. The protein kinase C activators, phorbol 12,13-dibutyrate (PDB) or sn-1,2-dioctanoylglycerol (DOG), inhibited histamine-stimulation of phospholipase C. This inhibition was prevented by the protein kinase C-selective inhibitor Ro 31-8220 (3-{1-[3-(2-isothioureido) propyl]indol-3-yl}-4-(1-methylindol-3-yl)-3-pyrrolin-2,5-dione) but not the broad spectrum protein kinase inhibitor staurosporine. Indeed staurosporine on its own inhibited both the histamine-stimulated response and, in permeabilized cells, phospholipase C activated by Ca2+. Staurosporine inhibition of phospholipase C is unlikely to be mediated via protein kinase A or Ca2+/calmodulin-dependent protein kinase because it was not reproduced by selective inhibition of these kinases. Staurosporine treatment, however, reduced inositol phospholipid levels in stimulated cells. Thus staurosporine and Ro 31-8220, two widely used protein kinase C inhibitors, have quite different effects on phospholipase C activation. Furthermore, staurosporine may cause this inhibition through a reduction in the level of phospholipase C substrate.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5306-85-4. Category: pyrrolines.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

In an article, author is Zhang, Ping, once mentioned the application of 56-12-2, Quality Control of 4-Aminobutyric acid, Name is 4-Aminobutyric acid, molecular formula is C4H9NO2, molecular weight is 103.1198, MDL number is MFCD00008226, category is pyrrolines. Now introduce a scientific discovery about this category.

2-[2-(4-Methoxyphenyl)vinyl]-3-[(2-maleimidyl)acetyl]-2,3-dihydro-1,3-benzothiazole

The crystal packing of the title compound {systematic name: 3-[(2,3-dioxo-3-pyrrolin-1-y1) acetyl]-2-[2-(4-methoxyphenyl)vinyl]-2,3- dihydro-1,3-benzothiazole}, C28H22N2O4S, is stabilized by intermolecular C-H…O and C-H…S hydrogen bonds and by pi-pi stacking interactions occurring between a benzene ring and the pyrrole ring of centrosymmetrically related molecules.

If you are interested in 56-12-2, you can contact me at any time and look forward to more communication. Quality Control of 4-Aminobutyric acid.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 57-71-6, Name is Diacetyl Monoxime, SMILES is C/C(C(C)=O)=NO, in an article , author is Shen, F, once mentioned of 57-71-6, Formula: C4H7NO2.

Inhibitory effect of 3,4-diaryl-3-pyrrolin-2-one derivatives on cyclooxygenase 1 and 2 in murine peritoneal macrophages

AIM: To develop a whole-cell assay based on murine peritoneal macrophages and evaluate the inhibitory effect of candidate compounds on cyclooxygenase-1 (COX-1) and COX-2. METHODS: Macrophages were stimulated with calcimycin or hpopolysaccharide (LPS) for various periods. Their abilities to convert endogenous arachidonic acid to 6-keto-PGF(1alpha) or PGE(2) were examined by radioimmunoassay (RIA). RNA level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and COX-1/2 was detected by reverse transcription polymerase chain reaction (RT-PCR) using specific primers. RESULTS: Rofecoxib selectively inhibited LPS-induced, COX-2-derived PGE(2) synthesis with an IC50 value of (4.7+/-0.5) nmol/L compared with maximum inhibitory ratio of 17.3 % for the inhibition of calcimycin induced, COX-1-derived 6-keto-PGF(1alpha) synthesis. Indomethacin exhibited dual inhibitory effects on COX-1 and COX-2 with IC50 of (4.7+/-1.1) nmol/L and (7.1+/-1.2) nmol/L, respectively. Two series of 17 compounds were tested. Most of compounds in series 11 showed comparable inhibitory activities to rofecoxib on COX-2. The relative position of the sulfonylphenyl group to the lactam carbonyl group has important effects on COX-2 inhibitory activity. CONCLUSION: The established whole cell assay is appropriate for drug-design oriented in vitro assay. 3,4-Diaryl-3-pyrrolin-2-one derivatives were proved to be prospective new type of COX-2 selective inhibitors.

Interested yet? Read on for other articles about 57-71-6, you can contact me at any time and look forward to more communication. Formula: C4H7NO2.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem