Tag: M.W:100-200

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4045-24-3, is researched, Molecular C6H13NO, about Design, synthesis and biological evaluation of Tozadenant analogues as adenosine A2A receptor ligands, the main research direction is morpholinyl benzothiazolyl methylpiperidine carboxamide preparation adenosine receptor fluorine isotopologue; A(2A) adenosine Receptor; Autoradiography; Binding studies; Fluorinated analogues; Fluorine-18 isotopologues; Ligand synthesis.Product Details of 4045-24-3.

With the aim to obtain potent adenosine A2A receptor (A2AR) ligands, a series of eighteen derivatives of 4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide were designed and synthesized. The target compounds were obtained by a chem. building block principle that involved reaction of the appropriate aminobenzothiazole Ph carbamates with either com. available or readily synthesized functionalized piperidines. Ki values for human A2AR ranged from 2.4 to 38 nM, with more than 120-fold selectivity over A1 receptors for all evaluated compounds except 4-Fluoro-4-(hydroxymethyl)-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)piperidine-1-carboxamide which had a Ki of 361 nM and 18-fold selectivity. The most potent fluorine-containing derivatives exhibited Ki values of 4.9 nM, 3.6 nM and 2.8 nM for the human A2AR. Interestingly, the corresponding values for rat A2AR were found to be four to five times higher. Their binding to A2AR was further confirmed by radiolabeling with 18F and in vitro autoradiog. in rat brain slices, which showed almost exclusive striatal binding and complete displacement by the A2AR antagonist ZM 241385. Authors conclude that these compounds represent potential candidates for the visualization of the A2A receptor and open pathways to novel therapeutic treatments of neurodegenerative disorders or cancer.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of nature product kinsenoside analogues with anti-inflammatory activity, published in 2021-01-01, which mentions a compound: 58081-05-3, Name is (R)-4-Hydroxydihydrofuran-2(3H)-one, Molecular C4H6O3, Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one.

Kinsenoside (I) is a major bioactive component in herbal medicines that possesses a broad range of pharmacol. functions. Goodyeroside A (II), an epimer of kinsenoside, remains less explored. In this report, the authors chem. synthesized kinsenoside, goodyeroside A and their analogs with glycan variation, chirality inversion at chiral center(s), and bioisosteric replacement of lactone with lactam. Among these compounds, goodyeroside A and its mannosyl counterpart III demonstrated superior anti-inflammatory efficacy. Furthermore, goodyeroside A was found to suppress inflammation through inhibiting the NF-κB signal pathway effectively. The structure-activity relationship is also explored for further development of more promising kinsenoside analogs as drug candidates.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4045-24-3, is researched, SMILESS is COC1CCNCC1, Molecular C6H13NOJournal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Electrochemical Iodoamination of Indoles Using Unactivated Amines, Author is Lei, Ning; Shen, Yanling; Li, Yujun; Tao, Pan; Yang, Liquan; Su, Zhishan; Zheng, Ke, the main research direction is green electrochem iodoamination indole unactivated amine amino acid benzotriazole.Electric Literature of C6H13NO.

An environmentally friendly electrochem. approach for iodoamination of various indole derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles (more than 80 examples) has been developed. This strategy was further applied in late-stage functionalization of natural products and pharmaceuticals and gram-scale synthesis and radiosynthesis of 131I-labeled compounds Fundamental insights into the mechanism of the reaction based on control experiments, d. functional theory calculation, and cyclic voltammetry are provided.

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Pyrroline – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 34941-92-9, is researched, Molecular C5H3ClFN, about The reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions, the main research direction is reactivity fluoropyridine chloropyridine sodium ethoxide nucleophilic aromatic heteroaromatic substitution.Computed Properties of C5H3ClFN.

The relative displacement rates of the halide substituent from 2-fluoro- and 2-chloropyridines by EtONa in EtOH at +25° were assessed by competition kinetics. The 2-fluoropyridine reacts 320 times faster than the chloro analog. A CF3 group increases the reactivity more than single halogen atoms do, whatever the element, and the latter are superior to Me3Si groups. Substituents accommodated at the 4-position operate through their inductive effect, whereas at the 3-position, this action may be attenuated by steric hindrance. Almost all 5-substituents enhance the rate of the nucleophilic substitution occurring at the 2-position. The sole exception concerns the F-atom at the 5-position which retards the reaction, presumably by lone-pair/lone-pair repulsion with the neg. charge building up at the central C-atom of the intermediate Meisenheimer complex. The substituent effects are additive. Therefore, by using the increments derived from the present work, the rates of future reactions should be predictable with fair accuracy.

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Pyrroline – Wikipedia,
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Recommanded Product: 34941-92-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Chloro-2-fluoropyridine, is researched, Molecular C5H3ClFN, CAS is 34941-92-9, about Cross-Electrophile Coupling of Unactivated Alkyl Chlorides. Author is Sakai, Holt A.; Liu, Wei; Le, Chi “Chip”; MacMillan, David W. C..

Overcoming intrinsic limitations of C(sp3)-Cl bond activation, the development of a novel organosilane reagent Si(TMS)3(N)R1R2 (R1 = adamantyl, tert-Bu, i-Pr, n-Bu; R2 = H) that can participate in chlorine atom abstraction under mild photocatalytic conditions were reported. In particular, the application of this mechanism to a dual nickel/photoredox catalytic protocol that enables the first cross-electrophile coupling of unactivated alkyl chlorides R3Cl (R3 = cyclohexyl, oxan-4-yl, 4-cyanobutyl, etc.) and aryl chlorides R4Cl (R4 = pyridin-4-yl, quinolin-3-yl, 2-(methylsulfanyl)pyrimidin-5-yl, etc.) was described. Employing these low-toxicity, abundant, and com. available organochloride building blocks, this methodol. allows access to a broad array of highly functionalized C(sp2)-C(sp3) coupled adducts, e.g., I including numerous drug analogs.

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Pyrroline – Wikipedia,
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Reference of 4-Methoxypiperidine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Amine-Responsive Disassembly of AuI-CuI Double Salts for Oxidative Carbonylation. Author is Cao, Yanwei; Yang, Jian-Gong; Deng, Yi; Wang, Shengchun; Liu, Qi; Shen, Chaoren; Lu, Wei; Che, Chi-Ming; Chen, Yong; He, Lin.

A sensitive amine-responsive disassembly of self-assembled AuI-CuI double salts was observed and its use for the synergistic catalysis was enlightened. Study of the disassembly of [Au(NHC)2][CuI2] revealed the contribution of Cu-assisted ligand exchange of N-heterocyclic carbene (NHC) by amine in [Au(NHC)2]+ and the capacity of [CuI2]- on the oxidative step. By integrating the implicative information coded in the responsive behavior and inherent catalytic functions of d10 metal complexes, a catalyst for the oxidative carbonylation of amines was developed. The advantages of this method were clearly reflected on mild reaction conditions and the significantly expanded scope (51 examples); both primary and steric secondary amines can be employed as substrates. The cooperative reactivity from Au and Cu centers, as an indispensable prerequisite for the excellent catalytic performance, was validated in the synthesis of (un)sym. ureas and carbamates.

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Pyrroline – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron called Pheromone synthesis. XXIV. Synthesis of optically active forms of ipsdienol and ipsenol. The pheromone components of Ips bark beetles, Author is Mori, K.; Takigawa, T.; Matsuo, T., which mentions a compound: 58081-05-3, SMILESS is O=C1OC[C@H](O)C1, Molecular C4H6O3, Formula: C4H6O3.

(R)-(-)- And (S)-(+)-ipsdienol (I) [(R)-(-)- and (S)-(+)-Me2C:CH(OH)CH2C(:CH2)CH:CH2, resp.] were prepared from (R)-(+)-glyceraldehyde acetonide and (R)-(+)-malic acid, resp., via the intermediate epoxide II and its enantiomer, resp. I is the naturally occurring form of this pheromone. Treating (S)- and (R)-isobutylethylene oxide with CH2:C(MgCl)CH:CH2 gave 32 and 50% (S)-(-)- and (R)-(+)-Me2CHCH2CH(OH)CH2C(:CH2)CH:CH2, resp.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2-Methylbenzo[d]oxazol-5-yl)methanol( cas:136663-38-2 ) is researched.Formula: C9H9NO2.Balaswamy, G.; Pradeep, P.; Srinivas, K.; Rajakomuraiah, T. published the article 《Design, synthesis and antimicrobial activity of novel 2-substituted benzoxazole derivatives》 about this compound( cas:136663-38-2 ) in International Journal of Chemical Sciences. Keywords: benzoxazole derivative preparation antimicrobial activity. Let’s learn more about this compound (cas:136663-38-2).

In the current research work, the title compounds were synthesized from Me 2-substituted benzoxazole-5-carboxylate by refluxing with methanol and THF (1 : 1) in presence of NaBH4, which afforded (2-substituted benzoxazol-5-yl)methanol, on partial oxidation with PCC furnished 2-substituted benzoxazole-5-carbaldehyde, on treatment with appropriate carbonyl compounds monoethyl malonate, Et acetoacetate or malonic acid yielded the corresponding α,β-unsaturated derivatives of 2-substituted benzoxazoles like, Et 3-(2-substituted benzoxazol-5-yl)acrylate, 4-(2-substituted benzoxazol-5-yl)but-3-en-2-one and 3-(2-substituted benzoxazol-5-yl)acrylic acid. The identification and characterization of all the synthesized compounds were confirmed by elemental anal., m.p., thin layer chromatog., FTIR, 1H NMR and mass spectral data. All the compounds were screened for antimicrobial activity. In view of interesting biol. activities and pharmacol. importance associated with benzoxazole derivatives, some of the derivatives of benzoxazole containing heterocyclic ring were prepared and their bio-potential were evaluated.

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Pyrroline – Wikipedia,
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Related Products of 4045-24-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Orally bioavailable HCV NS5A inhibitors of unsymmetrical structural class. Author is Nakamura, Hiroshi; Fujioka, Shingo; Terui, Takashi; Okuda, Satoshi; Kondo, Kentaro; Tamatani, Yoshinori; Akagi, Yusuke; Komoda, Yasumasa; Kinoshita, Wataru; Ito, Soichiro; Maeda, Kimiya; Ukaji, Yutaka; Inaba, Takashi.

A novel unsym. structural class of orally bioavailable hepatitis C virus (HCV) nonstructural 5A protein (NS5A) inhibitors has been generated by improving both the solubility and membrane permeability of the lead compound found in our previous work. The representative compound 14, with a 5-hydroxymethylpyrazine group and a 3-t-butylpropargyl group on each side of the mol., exhibited the best oral bioavailability in this study, inhibiting not only the HCV genotype 1a, 1b, 2a, and 3a replicons with EC50 values in the picomolar range, but also inhibited 1a Q30 mutants induced by launched sym. inhibitors with EC50 values in the low nanomolar range.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 34941-92-9, is researched, SMILESS is ClC1=CC(=NC=C1)F, Molecular C5H3ClFNJournal, Article, Organic Letters called Access to Highly Substituted 7-Azaindoles from 2-Fluoropyridines via 7-Azaindoline Intermediates, Author is Nuhant, Philippe; Allais, Christophe; Chen, Ming Z.; Coe, Jotham W.; Dermenci, Alpay; Fadeyi, Olugbeminiyi O.; Flick, Andrew C.; Mousseau, James J., the main research direction is azaindole preparation; azaindoline preparation regioselective electrophilic substitution bromination nitration oxidation; fluoronitroethylpyridine preparation oxidative Nef reaction reductive amination intramol SNAr; nitroolefin fluoropyridine metalation addition.Name: 4-Chloro-2-fluoropyridine.

A versatile synthesis of 7-azaindoles e. g., I, from substituted 2-fluoropyridines is described. C3-metalation and 1,4-addition to nitroolefins provide substituted 2-fluoro-3-(2-nitroethyl)pyridines. A facile oxidative Nef reaction/reductive amination/intramol. SNAr sequence furnishes 7-azaindolines. Finally, optional regioselective electrophilic C5-substitution (e.g., bromination or nitration) and subsequent in situ oxidation delivers highly functionalized 7-azaindoles in high overall efficiency.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem