Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.298690-72-9,2-(3-Fluorophenyl)pyrrolidine,as a common compound, the synthetic route is as follows.

e (RS)-2-(3-Fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine To a stirred solution of (RS)-2-(3-fluoro-phenyl)-pyrrolidine (0.24 g, 1.45 mmol) and triethylamine (0.40 ml, 2.87 mmol) in dichloromethane (40 ml) was added at 0 C. toluene-4-sulfonyl chloride (0.42 g, 2.20 mmol). The mixture was stirred at RT for 16 h, evaporated, dissolved in water (40 ml) and extracted with ethyl acetate (2*40 ml). The combined organic layers were washed with water (40 ml), brine (40 ml), dried (MgSO4) and evaporated. The crude product was purified by crystallization from ethyl acetate/hexane to give the product (0.38 g, 83%) as a white solid, m.p. 116 C. and MS: m/e=319 (M+)., 298690-72-9

As the paragraph descriping shows that 298690-72-9 is playing an increasingly important role.

Reference£º
Patent; Hoffmann- La Roche Inc.; US6284785; (2001); B1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem

30727-14-1, 1-Ethylpyrrolidin-3-ol is a pyrrolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

30727-14-1, EXAMPLE 170 Preparation of 4-[(1-Ethylpyrrolidin-3-yl)oxy]phenyl 2-[4-[2-(1-Pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl Ketone. STR515 Sodium hydride (60% oil dispersion, 38 mg) was suspended in DMF (1 mL) and stirred at ambient temperature for 15 min under argon before 1-ethyl-3-pyrrolidinol (92 muL) was added. After stirring for 15 min, 4-fluorophenyl 2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl ketone (223 mg) in 1 mL of DMF was introduced and the resulting solution was stirred at ambient temperature for 4 h. The reaction mixture was diluted with brine (50 mL) and extracted with EtOAc (3*50 mL). The combined organic layers were dried (Na2 SO4) and concentrated under reduced pressure. Chromatography with Et3 N:MeOH:EtOAc (5:5:90) afforded the product as a colorless oil (171 mg, 63%). 1 H NMR (CDCl3): delta 7.85 (m, 1H), 7.75 (d, 2H), 7.65 (m, 1H), 7.35 (d, 2H), 7.32 (m, 2H), 6.78 (d, 2H), 6.71 (d, 2H), 4.80 (m, 1H), 4.03 (t, 2H), 2.85 (t, 2H), 2.80 (m, 2H), 2.60 (m, 4H), 2.50 (m, 4H), 2.28 (m, 1H), 1.92 (m, 1H), 1.08 (t, 3H).

As the paragraph descriping shows that 30727-14-1 is playing an increasingly important role.

Reference£º
Patent; Eli Lilly and Company; US6025382; (2000); A;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem

99724-19-3, 3-Boc-Aminopyrrolidine is a pyrrolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. [1-(6-Amino-5-formyl-pyrimidin-4-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester To a suspension of 4-amino-6-chloro-pyrimidine-5-carbaldehyde (239 mg, 1.52 mmol) in CH3CN (2 mL) was added 3-(tert-butoxycarbonylamino)pyrrolidine (312 mg, 1.67 mmol), followed by DIEA (392.9 mg, 3.04 mmol). The mixture was stirred at 90 C. for 1 h. It was cooled to room temperature and the precipitate was filtered off, washed with CH3CN and dried in vacuo to afford the product as a white solid (290.6 mg, 62.2%). 1H NMR (DMSO-d6) delta 9.92 (s, 1H), 8.58 (br, 1H), 7.95 (s, 1H), 7.68 (br, 1H), 7.22 (d, J=6.16 Hz, 1H), 4.02 (m, 1H), 3.80 (m, 2H), 3.66 (m, 1H), 3.45 (m, 1H), 2.03 (m, 1H), 1.82 (m, 1H), 1.38 (s, 9H); LC/MS (ESI) calcd for C14H22N5O3 (MH)+ 308.2, found 308.3., 99724-19-3

The synthetic route of 99724-19-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gaul, Michael David; Xu, Guozhang; Baumann, Christian Andrew; US2006/281764; (2006); A1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.186550-13-0,1-Boc-3-Aminopyrrolidine,as a common compound, the synthetic route is as follows.

2-Chloro-5-((6-fluoro-2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)benzoic acid (700 mg,2.00mmol),EDC (770 mg, 4.00 mmol),HOBt (540 mg, 4.00 mmol), DIEA (0.9 mL, 5.00 mmol) and compound 1-Boc-3-aminopyrrolidine (400 mg, 2.08 mmol) were dissolved in anhydrous DMF (20 mL).The reaction was carried out overnight at room temperature under argon gas protection. Stop the reaction,The reaction was diluted with DCM / MeOH (10:1, 60 mL).The organic phase was saturated with sodium bicarbonate (30 mL).Wash with saturated ammonium chloride (30 mL) and saturated brine (30 mL¡Á3).Drying over MgSO 4, EtOAc (EtOAc)Recrystallization from DCM/PE gave a pale yellow solid 890mg.The yield is 85.6%.

186550-13-0, As the paragraph descriping shows that 186550-13-0 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Zhao Hailong; Ji Ming; Zhou Jie; Wang Liyuan; Yao Haiping; Jin Jing; (107 pag.)CN108727343; (2018); A;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem

163457-23-6, 3,3-Difluoropyrrolidine hydrochloride is a pyrrolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5.107 3-{4-[4-(3,3-DIFLUORO-PYRROLIDIN-1-YLMETHYL)-BENZYLOXY]-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL}-PIPERIDINE-2,6-DIONE To the stirred mixture of 3-(4-(4-(bromomethyl)benzyloxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione (350 mg, 0.8 mmol) and 3,3-difluoropyrrolidin hydrochloride (136 mg, 0.8 mmol) in DCM (10 mL) was added DIPEA (0.28 ml, 1.6 mmol). The resulting mixture was stirred at room temperature for 22 hrs and the reaction mixture was diluted by DCM (30 mL). The mixture was washed with water (20 mL) and brine (20 mL). Organic layer was dried by MgSO4 and concentrated. The residue was purified by ISCO to give 3-{-4-[4-(3,3-Difluoro-pyrrolidin-1-ylmethyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-piperidine-2,6-dione as a white solid (256 mg, 69% yield. HPLC: Waters Symmetry C-18, 3.9*150 mm, 5 mum, 1 mL/min, 240 nm, 20/80, (CH3CN/0.1% H3PO4), 3.59 min (98.6%); mp: 126-128 C.; 1H NMR (DMSO-d6) delta 1.91-2.04 (m, 1H, CHH), 2.15-2.34 (m, 2H, CH2), 2.35-2.44 (m, 1H, CHH), 2.60 (br. s., 1H, CHH), 2.69 (t, J=7.0 Hz, 2H, CH2), 2.76-3.01 (m, 3H, CHH, CH2), 3.62 (s, 2H, CH2), 4.20-4.32 (m, J=17.6 Hz, 1H, CHH), 4.42 (d, J=17.4 Hz, 1H, CHH), 5.11 (dd, J=5.1, 13.2 Hz, 1H, CHH), 5.23 (s, 2H, CH2), 7.22-7.37 (m, 4H, Ar), 7.39-7.63 (m, 3H, Ar), 10.97 (s, 1H, NH); 13C NMR (DMSO-d6) delta 22.33, 31.16, 34.92, 35.55 (t, JC-F=22.50 Hz), 51.30, 51.56, 58.24, 60.99 (t, JC-F=27.57 Hz), 69.35, 114.97, 115.22, 127.69, 128.62, 129.78, 129.93, 130.38, 133.30, 135.44, 137.63, 153.46, 167.97, 170.95, 172.80; LCMS MH=470; Anal. Calcd for C25H25F2N3O4+0.2H2O: C, 63.47; H, 5.41; N, 8.88; Found: C, 63.41; H, 5.46; N, 8.78., 163457-23-6

The synthetic route of 163457-23-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Man, Hon-Wah; Muller, George W.; Ruchelman, Alexander L.; Khalil, Ehab M.; Chen, Roger Shen-Chu; Zhang, Weihong; US2011/196150; (2011); A1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem