Tag: M.W:100-200

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

134272-64-3, To a solution of 1-(2-aminoethyl)-1H-pyrrol-2,5-dione 2,2,2-hydrochloride: (150mg, 0.849mmol) and TEA (350muL, 2.50mmol) in THF (4mL) was added (E)-perfluorophenyl 4-(phenyldiazenyl)benzoat 7 (666mg, 1.70mmol) in THF (4mL) dropwise. After 16h at rt, the solvent was evaporated, the resulting residue was dissolved in CHCl3 and washed with H2O (30mL), 1M HCl (30mL) and brine (30mL). The organic layer was dried over Na2SO4, filtered and concentrated. The crude product was purified by silica column (eluent EtOAc:hexane: 1:4?1:1; Rf:0.10?0.50) to yield the product as an orange solid (243mg; 82%). 1H NMR (500MHz, DMSO) delta 8.73 (t, J=6.0Hz, 1H), 7.96-7.88 (m, 6H), 7.67-7.56 (m, 3H), 7.01 (s, 2H), 3.62 (t, J=5.7Hz, 2H), 3.45 (dd, J=11.6, 5.9Hz, 2H); 13C NMR (126MHz, DMSO) delta 171.04, 165.76, 153.24, 151.89, 136.61, 134.51, 131.92, 129.49, 128.35, 122.67, 122.27, 37.71, 37.10; HPLC/MS (tr=13.92min; ESI) found: 349.1 (M+H)+, calc.: 349.1.

134272-64-3 N-(2-Aminoethyl)maleimide Hydrochloride 22118207, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Horstmann, Benjamin; Korbus, Michael; Friedmann, Tatjana; Wolff, Christiane; Thiele, Christina Marie; Meyer-Almes, Franz-Josef; Bioorganic Chemistry; vol. 57; (2014); p. 155 – 161;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]-L-valyl-N-{3-[{(1R)-1-[1-benzyl-4-(2,5-difluorophenyl)-1H-pyrrol-2-yl]-2,2-dimethylpropyl}(glycoloyl)amino]propyl}-L-alaninamide The title compound was prepared from Example M9 first by coupling with N-[(benzyloxy)carbonyl]-L-valyl-L-alanine in the presence of HATU and N,N-diisopropylethylamine. In the next step, the Z protective group was removed by hydrogenating for 1 hour over 10% palladium on activated carbon at RT under hydrogen standard pressure and then converting the deprotected intermediate into the title compound by coupling with (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid in the presence of HATU and N,N-diisopropylethylamine. LC-MS (Method 1): Rt=1.21 min; MS (ESIpos): m/z=777 (M+H)+., 25021-08-3

25021-08-3 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 319935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Trifluoroacetic Acid/N-(2-aminoethyl)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetamide (1:1) The title compound was prepared by classical methods of peptide chemistry from commercially available (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid and tert-butyl (2-aminoethyl)carbamate.

25021-08-3, As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

NHS ester, compound 5a (8.2 mg, 7.6 muiotaetaomicron) and l-(2-aminoethyl)-lH-pyrrole-2,5-dione hydrochloride (2.2 mg, 0.011 mmol) were dissolved in anhydrous dichloromethane (305 mu) at room temperature. DIPEA (2.66 mu, 0.015mmol) was added and the reaction and was stirred for 3.5 hours. The reaction mixture was concentrated and was purified by RPHPLC (CI 8 column, CH3CN/H2O, gradient, 35% to 55%). The desired product fractions were frozen and lyophilized to give maleimide, compound D5 as a solid white powder (5.3 mg, 58% yield). LCMS = 5.11 min (8 min method). MS (m/z): 1100.6 (M + 1)+.

134272-64-3, As the paragraph descriping shows that 134272-64-3 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; KOVTUN, Yelena; TAVARES, Daniel; RUI, Lingyun; CHITTENDEN, Thomas; (386 pag.)WO2017/4026; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

2973-17-3, 1-Allyl-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis Example f-III-5 Synthesis of Silicone Compound: 1 = m = n = 0, and X1 = X3 = Substituent A-6 in the Chemical Structure 1 Drip 4.14 parts of the compound f-II: N-aryl maleimide, 10 parts of toluene, and 0.055 parts of xylene solution of 2 % by weight platinum / 1,3-divinyl-1,1,3,3-tetramethyl disiloxane complex (manufactured by Sigma-Aldrich Co.) to a solution of 3.0 parts of silicone compound: (1,1,3,3-tetramethyl trisiloxane (manufactured by Tokyo Chemical Industry Co., Ltd.) and 3.0 parts of toluene in about 60 minutes while stirring at a room temperature followed by reaction under the same condition one night. Thereafter, distill away the solvent with a reduced pressure, conduct stripping treatment for two hours with a reduced pressure of 10 mmHg at 40 C and confirm disappearance of absorption (2155 cm-1 of Si-H in infra-red absorption spectrum to obtain 4.14 parts of the target silicone compound f-M5. The infra-red absorption spectrum graph is shown as Fig. 8E., 2973-17-3

The synthetic route of 2973-17-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ricoh Company, Ltd.; EP2520579; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2973-17-3,1-Allyl-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

Synthesis Example f-III-6 Synthesis of Silicone Compound: 1 = n = 0, m =1 in the Chemical Structure 6 Drip 3.08 parts of the compound f-II: N-aryl maleimide, 10 parts of toluene, and 0.043 parts of xylene solution of 2 % by weight platinum / 1,3-divinyl-1,1,3,3-tetramethyl disiloxane complex (manufactured by Sigma-Aldrich Co.) to a solution of 5.0 parts of silicone compound: (1,1,1,3,5,5,5-heptamethyl trisiloxane (manufactured by Sigma-Aldrich Co) and 5.0 parts of toluene in about 60 minutes while stirring at a room temperature followed by reaction under the same condition one night. Thereafter, distill away the solvent with a reduced pressure, conduct stripping treatment for two hours with a reduced pressure of 10 mmHg at 40 C and confirm disappearance of absorption (2155 cm-1 of Si-H in infra-red absorption spectrum to obtain 5.01 parts of the target silicone compound f-M6. The infra-red absorption spectrum graph is shown as Fig. 8F., 2973-17-3

As the paragraph descriping shows that 2973-17-3 is playing an increasingly important role.

Reference£º
Patent; Ricoh Company, Ltd.; EP2520579; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7544-75-4,3,4-Dihydro-2H-pyrrol-5-amine hydrochloride,as a common compound, the synthetic route is as follows.

7544-75-4, 1) 7,8-Dihydro-2H,6H-pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H)-dione In the manner described in Example 1–1), the entitled compound was obtained as colorless crystals from 2-iminopyrrolidine hydrochloride and phenoxycarbonylisocyanate. Melting Point: 201-202 C. NMR Spectrum (DMSO-d6): 2.87 (2H, t), 2.07 (2H, t), 3.82 (2H, t), 11.25 (1H, bs) IR Spectrum nu (KBr) cm-1: 3430, 3210, 3080, 1740, 1710, 1690, 1630, 1440, 1410

The synthetic route of 7544-75-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Pharmaceutical Co., Ltd.; US5232924; (1993); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of Example 2.160.3 (557.5 mg), 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid (272 mg) and O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (667 mg) in N, N-dimethylformamide (1.75 mL) at 0 C. was added N,N-diisopropylethylamine (0.459 mL). The resulting mixture was stirred at 0 C. for 1 hour. The reaction mixture was mixed with saturated aqueous NH4Cl mixture, extracted with ethyl acetate and washed with brine. The organic layer was dried over sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography, eluting with petroleum ether/ethyl acetate (2/1), to provide the title compound. MS (LC-MS) m/e 795.3 (M+Na)+.

25021-08-3, The synthetic route of 25021-08-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AbbVie Inc.; Benatuil, Lorenzo; Bruncko, Milan; Chao, Debra; Izeradjene, Kamel; Judd, Andrew S.; Phillips, Andrew C.; Souers, Andrew J.; Thakur, Archana; (556 pag.)US2017/355769; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

6913-92-4, 1-Benzyl-3-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6913-92-4, 6.01.28.02 Benzyl-2,5-dihydro-1H-pyrrole-1-carboxylate 43 mL benzyloxycarbonyl chloride in 135 mL dichlormethane was added to 17.6 g 1-benzyl-2,5-dihydro-1H-pyrrole in 135 mL dichlormethane at 0 C. in 60 min. The mixture was stirred 3 h at RT and washed with saturated sodium hydrogencarbonate solution. The organic layer was dried and evaporated. The residue was purified by chromatography on silica gel (hexane/ethyl acetate: 5/1) to give 19.7 g of the desired product. Rt: 16.50 min. (method AG)

As the paragraph descriping shows that 6913-92-4 is playing an increasingly important role.

Reference£º
Patent; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WELLENZOHN, Bernd; US2013/143870; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134272-64-3,N-(2-Aminoethyl)maleimide Hydrochloride,as a common compound, the synthetic route is as follows.

(SPDB-Ala-Gly-Gly)2-Lys-P-Ala-ONHS (22 mg, 0.020 mmol) was dissolved in anhydrous dimethyl formamide (400 mu) to which was added DM4 (30 mg, 0.038) with magnetic stirring. After 2 min deionized water (20 mu) was added then after 15 min diisopropylethyl amine (10 mu, mmol) and H2N-(CH2)2-Mal HC1 salt (3.7 mg, 0.022 mmol) were added. After an additional 30 min, sample was injected directly onto a 19 mm x 150 mm C18 HPLC column eluting with deionized water containing 0.2% formic acid with a 5-95% linear acetonitrile gradient. Flow rate was 20 mL/min. Fractions containing pure desired product were combined and frozen then lyophilized to give 19 mg (38% yield) of product as a white solid. MS [M + Na]+ calcd.2491.0; found 2491.3., 134272-64-3

The synthetic route of 134272-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; WIDDISON, Wayne, C.; CHARI, Ravi, V.J.; WO2014/194030; (2014); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem