Tag: M.W:100-200

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Total synthesis of (+)-phrymarolin I from (+)-malic acid, the main research direction is phrymarolin I stereoselective total synthesis; furofuran ring system; lignan insecticidal haedoxan preparation.Electric Literature of C4H6O3.

(+)-Phrymarolin I (I) was stereoselectively synthesized from (R)-(+)-3-hydroxybutanolide that had been prepared via regioselective reduction of (+)-malic acid or microbial reduction of 4-tert-butoxyacetoacetate. The procedure is more efficient than the previous synthesis in terms of fewer reaction steps and the easier availability of the starting material.

There are many compounds similar to this compound(58081-05-3)Electric Literature of C4H6O3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Recommanded Product: (R)-4-Hydroxydihydrofuran-2(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Glycosidic constituents from in vitro Anoectochilus formosanus.

The glycosidic constituents of whole plants of Anoectochilus formosanus propagated by tissue culture were investigated. A new compound, 2-(β-D-glucopyranosyloxymethyl)-5-hydroxymethylfuran, along with the known compounds, 3-(R)-3-β-D-glucopyranosyloxybutanolide (kinsenoside), 3-(R)-3-β-D-glucopyranosyloxy-4-hydroxybutanoic acid, 1-O-isopropyl-β-D-glucopyranoside, (R)-(+)-3,4-dihydroxybutanoic acid γ-lactone, 4-(β-D-glucopyranosyloxy)benzyl alc., (6R,9S)-9-hydroxy-megastigma-4,7-dien-3-one-9-O-β-D-glucopyranoside, and corchoionoside C were isolated.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron called Enantiomerically pure β,γ-epoxyesters from β-hydroxylactones: synthesis of β-hydroxyesters and (-)-GABOB, Author is Larcheveque, M.; Henrot, S., which mentions a compound: 58081-05-3, SMILESS is O=C1OC[C@H](O)C1, Molecular C4H6O3, Safety of (R)-4-Hydroxydihydrofuran-2(3H)-one.

The preparation of enantiomerically pure β,γ-epoxy esters was achieved by chemoselective opening of β-hydroxybutanolides with Me3SiI followed by cyclization of the resulting iodohydrins with Ag2O. The reaction of these epoxy esters with lithio- or magnesiocuprates afforded stereochemically pure α-substituted-β-hydroxy esters. Alternatively, the title compound, (R)-H2NCH2CH(OH)CH2CO2H, was synthesized in optically pure form from the iodohydrin (R)-ICH2CH(OH)CH2CO2Et.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines, published in 2020-07-02, which mentions a compound: 4045-24-3, mainly applied to aniline alkylamine oxalamide copper catalyst amination directing group; aromatic amine preparation, Application of 4045-24-3.

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Electric Literature of C5H3ClFN. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-Chloro-2-fluoropyridine, is researched, Molecular C5H3ClFN, CAS is 34941-92-9, about C-O Cross-Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols. Author is Maligres, Peter E.; Li, Jing; Krska, Shane W.; Schreier, John D.; Raheem, Izzat T..

The authors describe a Pd/Josiphos catatyst system for alkoxylation of activated aryl and heteroaryl halides with primary, secondary, and select tertiary alcs. E.g., in presence of [Pd2(dba)3] and ligand CyPF-tBu (I), C-O cross-coupling of 4-chloro-2-methylquinoline and PhCH2CH2OH gave 99% aromatic ether 4-(2-phenylethoxy)-2-methylquinoline.

There are many compounds similar to this compound(34941-92-9)Electric Literature of C5H3ClFN. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Recommanded Product: 4045-24-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Methoxypiperidine, is researched, Molecular C6H13NO, CAS is 4045-24-3, about Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS. Author is Kabeche, Stephanie; Aida, Jumpei; Akther, Thamina; Ichikawa, Takashi; Ochida, Atsuko; Pulkoski-Gross, Michael J.; Smith, Mark; Humphries, Paul S.; Yeh, Ellen.

A series of novel thiazole-containing amides such as I.TFA were synthesized as inhibitors of Plasmodium falciparum farnesyldiphosphate synthase (PfFPPS) and geranylgeranyldiphosphate synthase (PfGGPPS). A structure-activity relationship study of these compounds led to the identification of potent and selective PfFPPS/GGPPS inhibitors with good in vitro ADME profiles. The most promising candidate mols. were progressed to mouse in vivo PK studies and demonstrated adequate free drug exposure to warrant further investigation.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 34941-92-9, is researched, SMILESS is ClC1=CC(=NC=C1)F, Molecular C5H3ClFNJournal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Total Synthesis of (-)-Maximiscin, Author is McClymont, Kyle S.; Wang, Feng-Yuan; Minakar, Amin; Baran, Phil S., the main research direction is maximiscin enantioselective total synthesis.Name: 4-Chloro-2-fluoropyridine.

A short, enantioselective synthesis of (-)-maximiscin (I), a structurally intriguing metabolite of mixed biosynthetic origin, is reported. A retrosynthetic anal. predicated on maximizing ideality and efficiency led to several unusual disconnections and tactics. Formation of the central highly oxidized pyridone ring through a convergent coupling at the end of the synthesis simplified the route considerably. The requisite building blocks could be prepared from feedstock materials (derived from shikimate and mesitylene). Strategies rooted in hidden symmetry recognition, C-H functionalization, and radical retrosynthesis played key roles in developing this concise route.

In addition to the literature in the link below, there is a lot of literature about this compound(4-Chloro-2-fluoropyridine)Name: 4-Chloro-2-fluoropyridine, illustrating the importance and wide applicability of this compound(34941-92-9).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Murai, Norio; Yonaga, Masahiro; Tanaka, Keigo published the article 《Palladium-Catalyzed Direct Hydroxymethylation of Aryl Halides and Triflates with Potassium Acetoxymethyltrifluoroborate》. Keywords: alc arylmethyl preparation coupling potassium acetoxymethyltrifluoroborate aryl halide triflate; cross coupling Suzuki Miyaura potassium acetoxymethyltrifluoroborate aryl halide triflate; hydroxymethylation acetoxymethyltrifluoroborate aryl halide triflate palladium catalyzed.They researched the compound: (2-Methylbenzo[d]oxazol-5-yl)methanol( cas:136663-38-2 ).Recommanded Product: (2-Methylbenzo[d]oxazol-5-yl)methanol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:136663-38-2) here.

Suzuki-Miyaura cross-coupling reactions of aryl halides and triflates with potassium acetoxymethyltrifluoroborate afforded the corresponding aryl and heteroaryl methanol products in moderate to excellent yields.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Synthesis of a new cerebroside isolated from Typhonium giganteum Engl, the main research direction is typhoniside cerebroside asym preparation; sn2 nucleophilic substitution typhoniside preparation.Related Products of 58081-05-3.

The stereoselective synthesis of typhoniside, a new cerebroside isolated from Typhonium giganteum Engl. was accomplished. Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin-producing cells and are composed by C18-4, 8-sphingadienine, α-hydroxy acid and a saccharide head. In this paper, C18-4, 8-sphingadienine was synthesized from D-xylose via a SN2 type reaction. α-Hydroxy acid was prepared from (R)-4-hydroxyte-trahydrofuran-2-one, which in turn could be obtained from L-ascorbic acid.

If you want to learn more about this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Related Products of 58081-05-3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(58081-05-3).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ) is researched.Electric Literature of C4H6O3.Luk, Kin Chun; Wei, Chung Chen published the article 《Preparation of derivatives of (R)-1,2,4-butanetriol from L-ascorbic acid》 about this compound( cas:58081-05-3 ) in Synthesis. Keywords: butanetriol derivative; ascorbic acid conversion butanetriol derivative. Let’s learn more about this compound (cas:58081-05-3).

L-Threonate (I; R = H), obtained from L-ascorbic acid, was converted to thiocarbonate [I; R = PhOC(S)], which on deoxygenation with Bu3SnH/AIBN gave dihydroxybutanoate II. Treatment of II with aqueous H2SO4 in THF gave lactone III, while reduction of II with LiAlH4 gave butanetriol IV.

If you want to learn more about this compound((R)-4-Hydroxydihydrofuran-2(3H)-one)Electric Literature of C4H6O3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(58081-05-3).

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem