Tag: M.W:100-200

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4045-24-3, is researched, Molecular C6H13NO, about Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration, the main research direction is amino amide preparation; alkene hydroxylamine copper catalyst aminoarylation.Name: 4-Methoxypiperidine.

A new strategy for aminoarylation of alkenes by copper-catalyzed SMILESs rearrangement using O-benzoylhydroxylamines as the amine reagent was described.. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Toshima, Hiroaki; Goto, Takashi; Ichihara, Akitami published the article 《Total syntheses of oscillatoxin D and 30-methyloscillatoxin D》. Keywords: oscillatoxin methyloscillatoxin D total synthesis.They researched the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ).Synthetic Route of C4H6O3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:58081-05-3) here.

The first total syntheses of oscillatoxin D and 30-methyloscillatoxin D have been accomplished. The construction of the spiroether has been achieved by intramol. Michael-type addition as a key step based on a possible biomimetic pathway.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Safety of (R)-4-Hydroxydihydrofuran-2(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Chiral, biomimetic total synthesis of (-)-aplysistatin.

The marine antineoplastic agent aplysistatin (I), from Aplysia angasi, was prepared enantiospecifically in 6 steps from R-(+)-malic acid. The key step was the biomimetic cyclization of lactone II with 2,4,4,6-tetrabromocyclohexa-2,5-dienone in MeNO2 at 20° for 2 h to give a 19:81 mixture of dihydroaplysistatins III (β-Br, β-Me, α-H; α-Br, α-Me, β-H).

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yin, Wei; Qiao, Chunhua researched the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ).Product Details of 58081-05-3.They published the article 《Synthesis of Epigoitrin from (R)-(+)-4-Hydroxy-γ-butyrolactone》 about this compound( cas:58081-05-3 ) in Journal of Heterocyclic Chemistry. Keywords: epigoitrin preparation. We’ll tell you more about this compound (cas:58081-05-3).

Epigoitrin (I) is one of the major components of several natural species, including Isatis tinctoria (Isatis indigotica) Fort, Brassica rapa rapa (turnip) and Brassica oleracea capitata (cabbage). It presents antithyroid and antivirus activities. The synthesis of the target compounds was achieved using com. available (R)-(+)-4-hydroxy-γ-butyrolactone as a starting material.

After consulting a lot of data, we found that this compound(58081-05-3)Product Details of 58081-05-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Application In Synthesis of 4-Chloro-2-fluoropyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Chloro-2-fluoropyridine, is researched, Molecular C5H3ClFN, CAS is 34941-92-9, about Selective C-H Fluorination of Pyridines and Diazines Inspired by a Classic Amination Reaction. Author is Fier, Patrick S.; Hartwig, John F..

Fluorinated heterocycles are prevalent in pharmaceuticals, agrochems., and materials. However, reactions that incorporate fluorine into heteroarenes are limited in scope and can be hazardous. The authors present a broadly applicable and safe method for the site-selective fluorination of a single carbon-hydrogen bond in pyridines and diazines using com. available silver(II) fluoride. The reactions occur at ambient temperature within 1 h with exclusive selectivity for fluorination adjacent to nitrogen. The mild conditions allow access to fluorinated derivatives of medicinally important compounds, as well as a range of 2-substituted pyridines prepared by subsequent nucleophilic displacement of fluoride. Mechanistic studies demonstrate that the pathway of a classic pyridine amination can be adapted for selective fluorination of a broad range of nitrogen heterocycles.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Category: pyrrolines. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about Synthesis of Epigoitrin from (R)-(+)-4-Hydroxy-γ-butyrolactone. Author is Yin, Wei; Qiao, Chunhua.

Epigoitrin (I) is one of the major components of several natural species, including Isatis tinctoria (Isatis indigotica) Fort, Brassica rapa rapa (turnip) and Brassica oleracea capitata (cabbage). It presents antithyroid and antivirus activities. The synthesis of the target compounds was achieved using com. available (R)-(+)-4-hydroxy-γ-butyrolactone as a starting material.

After consulting a lot of data, we found that this compound(58081-05-3)Category: pyrrolines can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Product Details of 52208-50-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,6-Dichloro-3-fluoropyridine, is researched, Molecular C5H2Cl2FN, CAS is 52208-50-1, about New synthesis method of 2,6-dichloro-3-fluoropyridine. Author is Yang, Weiqing; Lin, Yicheng; Wang, Xiaoning.

2, 6-Dichloro-3-nitropyridine was synthesized from 2, 6-dichloropyridine by nitrification reaction. Then 2,6-dichloro-3-aminopyridine was synthesized from 2,6-dichloro-3-nitropyridine by the catalytic hydrogenation reduction reaction. At last, 2,6-dichloro-3-fluoropyridine was synthesized from 2,6-dichloro-3-aminopyridine by the diazotization reaction. Overall yield of three steps reaction was 69.3%. The target compound was confirmed by MS and NMR. The factors such as nitric acid concentration, the type and amount of catalyst and the molar ratio of sodium nitrite were discussed in detail. This synthesis route has high yield, high selectivity, and better prospect of industrialization.

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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Aliphatic and aromatic glucosides from Anoectochilus koshunensis》. Authors are Ito, Aiko; Kasai, Ryoji; Yamasaki, Kazuo; Sugimoto, Hiroyuki.The article about the compound:(R)-4-Hydroxydihydrofuran-2(3H)-onecas:58081-05-3,SMILESS:O=C1OC[C@H](O)C1).Synthetic Route of C4H6O3. Through the article, more information about this compound (cas:58081-05-3) is conveyed.

A new simple aliphatic glucoside, 3-(R)-3-β-D-glucopyranosyloxybutanolide (kinsenoside) with its congeners and a heterocyclic aromatic glucoside, β-glucopyranosyl-3-pyridinemethanol (nicoloside) were isolated from whole plants of A. koshunensis. Their structures were elucidated from chem. and spectroscopic evidence.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

HPLC of Formula: 58081-05-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one, is researched, Molecular C4H6O3, CAS is 58081-05-3, about A Concise Stereoselective Total Synthesis of Methoxyl Citreochlorols and Their Structural Revisions. Author is Sunnapu, Ranganayakulu; Rajendar, Goreti.

A concise, stereoselective and protecting group free approaches for the total synthesis of (-)-(2S,4R)- and (+)-(2R,4S)-3′-methoxyl citreochlorols, e.g., I, and their stereoisomers are demonstrated. All four stereoisomers were synthesized to establish the absolute stereochem. of the reported structures and the structures were revised accordingly. The approach involves chelation controlled regioselective reduction of a diester, silyl iodide promoted ring-opening iodo esterification of lactones, highly chemo- and regioselective ring-opening of an epoxy ester, dichloromethylation of a carboxyl group, and syn- and anti-selective reduction of the resulted β-hydroxy ketone as key steps.

After consulting a lot of data, we found that this compound(58081-05-3)HPLC of Formula: 58081-05-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Straubinger, Markus; Bau, Brigitte; Eckstein, Susanne; Fink, Margit; Winterhalter, Peter published an article about the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3,SMILESS:O=C1OC[C@H](O)C1 ).Computed Properties of C4H6O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:58081-05-3) through the article.

The methanolic extract of saffron was separated with the aid of multilayer coil countercurrent chromatog. After purification by HPLC, the following seven novel carotenoid metabolites were identified on the basis of their spectral (UV, FTIR, MS, NMR, CD) data: (4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-enecarbaldehyde O-β-D-gentiobioside (1), (4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-enecarboxylic acid O-β-D-glucopyranoside (2), 6-hydroxy-3-(hydroxymethyl)-2,4,4-trimethylcyclohexa-2,5-dienone 6-O-β-D-glucopyranoside (3), (2Z)-3-methylpent-2-enedioic acid 1-[1-(2,4,4-trimethyl-3,6-dioxocyclohexenyloxy)-O-β-D-glucopyranosid-6-yl] ester (4), (5S)-5-hydroxy-7,7-dimethyl-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one O-β-D-glucopyranoside (5), (1R,5S,6R)-5-(hydroxymethyl)-4,4,6-trimethyl-7-oxabicyclo[4.1.0]heptan-2-one O-β-D-glucopyranoside (6), and (1R)- 3,5,5-trimethylcyclohex-3-enol O-β-D-glucopyranoside (7).

Although many compounds look similar to this compound(58081-05-3)Computed Properties of C4H6O3, numerous studies have shown that this compound(SMILES:O=C1OC[C@H](O)C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem