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Compounds with electron donor and electron acceptor functionality

Compounds containing both electron donor and electron acceptor functionality are suitable for use in adhesives. The electron donor group is a carbon to carbon double bond attached to an aromatic ring and conjugated with the unsaturation in the ring. The electron acceptor group is a maleimide, acrylate, fumarate or maleate.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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THE WAVENUMBERS OF C=O STRETCHING VIBRATIONS OF MALEINIMIDES

The infrared spectra in the region of fundamental C=O stretching vibrations in tetrachloromethane and chloroform were measured for 59 maleinimide derivatives.A linear correlation between the wavenumbers of symmetric and antisymmetric C=O stretching vibrations was found for a series of 102 experimental data obtained in both solvents.The slope of the nus(C=O) vs nuas(C=O) dependence as well as the degree of the vibrational coupling in imide system were discussed and compared with those for analogical five-membered cyclic 1,3-diketones.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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Acute effects of alkylating agents on canine renal function: Specifically designed synthetic maleimides

Maleimidohippurates and maleimidobenzoates were synthesized that possess a carboxy group for active uptake into renal proximal tubular cells and a reactive maleimide moiety to covalently bond with proximal tubular components. The reactivity of the maleimide moiety in each series was progressively reduced by substitution of methyl groups in place of the vinyl hydrogens. In contrast to N-ethylmaleimide (NEM), the resulting maleimidohippurates and maleimidobenzoates did not possess significant diuretic activity in the dog following renal arterial administration. However, as predicted, the nephrotoxicity of the maleimidohippurates paralleled their in vitro alkylating ability and was quite specifically located in the proximal portion of the canine renal tubule.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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ENZYMATIC FORMATION OF PROTOPINES BY A MICROSOMAL CYTOCHROME P-450 SYSTEM OF CORYDALIS VAGINANS

A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)-cis-N-methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing protopine alkaloids; the monooxygenase was solubilized, partially purified (100-fold) and characterized.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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A bacterial quorum-sensing precursor induces mortality in the marine coccolithophore, Emiliania huxleyi

Interactions between phytoplankton and bacteria play a central role in mediating biogeochemical cycling and food web structure in the ocean. However, deciphering the chemical drivers of these interspecies interactions remains challenging. Here, we report the isolation of 2-heptyl-4-quinolone (HHQ), released by Pseudoalteromonas piscicida, a marine gamma-proteobacteria previously reported to induce phytoplankton mortality through a hitherto unknown algicidal mechanism. HHQ functions as both an antibiotic and a bacterial signaling molecule in cell-cell communication in clinical infection models. Co-culture of the bloom-forming coccolithophore, Emiliania huxleyi with both live P. piscicida and cell-free filtrates caused a significant decrease in algal growth. Investigations of the P. piscicida exometabolome revealed HHQ, at nanomolar concentrations, induced mortality in three strains of E. huxleyi. Mortality of E. huxleyi in response to HHQ occurred slowly, implying static growth rather than a singular loss event (e.g., rapid cell lysis). In contrast, the marine chlorophyte, Dunaliella tertiolecta and diatom, Phaeodactylum tricornutum were unaffected by HHQ exposures. These results suggest that HHQ mediates the type of inter-domain interactions that cause shifts in phytoplankton population dynamics. These chemically mediated interactions, and other like it, ultimately influence large-scale oceanographic processes.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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A sensitive and selective liquid chromatography-tandem mass spectrometry method for simultaneous determination of five isoquinoline alkaloids from Chelidonium majus L. in rat plasma and its application to a pharmacokinetic study

Chelidonium majus L. is one of the most important medicinal plants of the family Papaveraceae. Its pharmacological effects have been primarily attributed to the presence of a number of alkaloids. In the present study, a sensitive and selective liquid chromatography-tandem mass spectrometry method for simultaneous determination of five isoquinoline alkaloids from Chelidonium majus L. was developed and validated. The analytes (protopine, chelidonine, coptisine, sanguinarine and chelerythrine), together with the internal standard (palmatine), were extracted from acidified rat plasma with ethyl acetate-dichloromethane (4:1, v/v). Chromatographic separation was carried out on a Diamonsil C18 column with an isocratic mobile phase consisting of acetonitrile and water (adjusted to pH 2.3 with formic acid) (30:70, v/v) at a flow rate of 0.4 ml/min. Mass spectrometric detection was performed by selected reaction monitoring mode via electrospray ionization source operating in positive ionization mode. The assay exhibited good linearity (r ? 0.9933) for all the analytes. The lower limits of quantification were 0.197-1.27 ng/ml using only 50 mul of plasma sample. The intra- and inter-day precisions were less than 11.9%, and the accuracy was between -6.3% and 9.3%. The method was successfully applied to the pharmacokinetic study of the five alkaloids in rats after intragastric administration of Chelidonium majus L. extract. Copyright 2013 John Wiley & Sons, Ltd. Copyright

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Pyrroline – Wikipedia,
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ALKALOIDS OF Dicentra

Methanolic extraction of Dicentra spectabilis L., collected in the flowering period in the botanical garden of Pyatigrsk Pharmaceutical Institute, has yielded 0.17percent of combined alkaloids from the epigeal part and 0.25percent from the roots.By the separation of these materials, dihydrosanguinarine, sanguinarine, scoulerine, cheilanthifoline, corydine, and protopine have been obtained.Dicentra peregrina Rudolph, collected in the flowering period on the island of Sakhalin, has yielded 1.8percent of combined alkaloids from the epigeal part and 1.51percent from the roots.From these combined materials have been isolated isocorydine, corydine, dicentrine, protopine, dihydrosanguinarine, sanguinarine, cheilanthifoline, bicuculline, lederine, scoulerine, isoboldine, predicentrine, reticuline, and allocryptopine.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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ALKALOIDS OF Papaver argemone L. AND Papaver pavonium Fisch. et MEY. FROM THE Argemonorhoeades FEDDE SECTION

Papaver argemone L. and Papaver pavonium FISCH. et MEY. species of the Argemonorhoeades FEDDE (Papaveraceae) section were studied.A very low content of alkaloids was found in both species (less than 0.05percent).P. argemone contains corytuberine and its quaternary N-methyl derivative magnoflorine as the dominant bases.As minor constituents were isolated: protopine, isocorydine, scoulerine, and alkaloids PAR 1, PAR 2, PAR 3.Chromatographic analysis detected allocryptopine, cryptopine, coptisine and traces of rhoeadine, papaverrubines C, D and E, and more than 6 unidentified bases.P. pavonium gave N2-methyl-1,2,3,4-tetrahydro-beta-carboline as the dominant alkaloid, along with minor amounts of the tertiary bases protopine, allocryptopine, corydine, isocorydine and corytuberine.Of quaternary bases, coptisine, magnoflorine and an unidentified alkaloid PP 1 were isolated.The presence of many other, considerably labile bases has been proven in both species

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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Synergistic effects of Ginseng C. A. Mey and Astragalus membranaceus (Fisch.) Bunge on activating mice splenic lymphocytes detected by microcalorimetry and the underlying mechanisms predicted by in silico network analysis

The aim of the current study was to investigate the combination effect of Ginseng C. A. Mey (ginseng) and Astragalus membranaceus (Fisch.) Bunge (astragalus) which are commonly used for strengthening immune system. In this study, the effects of ginseng, astragalus and their combination on activating mice splenic lymphocytes were studied by microcalorimetry in vitro. The parameters of Pmax, Q and Tmax of heat-production curve in spleen lymphocytes were recorded and analyzed, as well as their association with drug concentration. Through the combination index analysis, it was found that ginseng and astragalus could induce the heat generation of splenic lymphocytes. Network analysis was used to investigate the mechanisms, which showed that their combination may cause immune activation in the body through several signaling pathways such as T cell receptor signaling pathway and PI3?K-Akt signaling pathway.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

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Antiprotozoal alkaloids from Galanthus trojanus

Two new alkaloid N-oxides, 1-O-acetyldihydromethylpseudolycorine N-oxide, and 11-hydroxyvittatine N-oxide, ten known alkaloids; arolycoricidine, haemanthamine, O-methylnorbelladine, narcidine, dihydrolycorine, 8-O-demethylmaritidine, stylopine and protopine, nicotinic acid and tyramine were isolated from Galanthus trojanus A.P. Davis & N. Oezhatay (Amaryllidaceae). The chemical structures of the isolates were elucidated by UV, IR, MS, CD, 1D and 2D NMR experiments. The in vitro antiprotozoal and cytotoxic potentials of the compounds were also evaluated.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem