Some scientific research about 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1081-17-0, Name is 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione, molecular formula is C11H9NO3

ALKALOIDS OF Corydalis paniculigera

The alkaloid composition of the roots of Corydalis paniculigera Rgl., collected in the flowering phase in the Alai range, has been studied.Chloroform extraction yielded 0.39percent of total alkaloids, from which were isolated wilsonirine, thalicmidine, coclaurine, stylopine, dihydrosanguinarine, sanguinarine, oxosanguinarine, adlumine, adlumidine, bicucculine, sibiricine, protopine, pancorine, and corunnine, and new alkaloids which have been called pancoridine (I) and pancorinine (II).The structures of (I) and (II) have been established on the basis of spectral characteristics and also the production of wilsonirine on their reduction in sulfuric acid.

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Extended knowledge of 1081-17-0

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Conversion of Protopine into the Secoberbines Corydalisol and Hypecorine

Pyrolysis of protopine N-oxide (6) leads to the dibenzoxazacycloundecine (7) whose reduction with palladium catalyst affords (+/-)-corydalisol (2).Alternatively, zinc in acetic acid treatment of (7) leads to (+/-)-hypecorine (3) and (+/-)-corydalisol (2).

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Isoquinoline alkaloids from Thalictrum delavayi

Two new protoberberine alkaloids, 2,3,9,10-dimethylenedioxy-8-oxoprotoberberine (1) and 2,3,9,10-dimethylenedioxy-l,8-dihydroxyprotoberberine (2), together with nine known isoquinoline-type alkaloids were isolated from the roots of Thalictrum delavayi. Their structures were elucidated by spectral methods. Among these compounds, pseudoprotopine showed competitive inhibition activity by DA receptor binding assay (D1) in vitro. The competitive inhibitions were 87.5% (10-4 M) and 15.6% (10-6 M), respectively.

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A new application about 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione

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Systems pharmacology-based dissection of the active ingredients and targets of Yiqi Zishen formula for application to COPD

In this work, a systems pharmacology model based on the pharmacokinetic analysis, drug targeting, and drug-target-disease network analyses, was applied specifically to uncover the active ingredients and therapeutic targets of Yiqi Zishen formula (YZF). Furthermore, a rat model of cigarette smoke-and bacterial infection-induced chronic obstructive pulmonary disease (COPD) was applied to evaluate the effects of YZF on COPD and its comorbidity. The expression of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, soluble TNF-alpha receptor (sTNFR2), matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of MMP (TIMP)-1, endothelin (ET)-1, transforming growth factor (TGF)-beta, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) were analyzed by immunohistochemistry. The pharmacological system efficiently generated 158 active compounds from YZF, and predicted 192 potential targets. The result showed that there was a significant target overlap between the 12 herbs in the YZF formula, which means that each herb of YZF connected with the similar targets, implying the synergistic effects among them. The target-disease network results indicated that YZF was effective in treating various pathological conditions, including respiratory tract diseases, cardiovascular disease, immune system diseases, and nervous system diseases. The therapeutic mechanisms of YZF were probably associated with modulation of inflammatory response, immune responses, matrix metalloproteinases expression, among others. In follow-up experiments, we found that YZF was effective for the treatment of COPD and its comorbidity such as ventricular hypertrophy, by inhibiting the expression of inflammatory cytokine, matrix metalloproteinases, and hypertrophic stimuli and collagen, in vivo.

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1122-10-7, Name is 3,4-Dibromo-1H-pyrrole-2,5-dione, belongs to pyrrolines compound, is a common compound. Formula: C4HBr2NO2In an article, once mentioned the new application about 1122-10-7.

New synthetic route to granulatimide and its structural analogues.

The Stille coupling reaction of stannylindole 12 with 4-iodoimidazole 13 (or 24) in the presence of PdCl(2)(PPh(3))(2) gave the corresponding indole-imidazole coupling product 14 (or 25), thereby affording a new synthetic approach to the alkaloid granulatimide (7), isolated from the Brazilian ascidian Didemnum granulatum, as well as its structural analogues, 10-methylgranulatimide (23), 17-methylgranulatimide (30), 10,17-dimethylgranulatimide (31).

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ON ALKALOIDS OF THREE Papaver SPECIES FROM THE SECTION Scapiflora REICHB.

The main alkaloid of the aerial part of P. croceum LEDEB. was nudaurine (I), isolated for the first time.In addition to amurine, known to be present in this species, oxysanguinarine (II) and corydine (IIIa) were also newly isolated and the presence of papaverrubine D demonstrated.In the fraction of tertiary bases from P.kerneri HAYEK allocryptopine and epialpinine (IV) were isolated as further alkaloids in addition to the already known alkaloids amurensine (the main alkaloid), amurensinine, amurine, alpinigenine, muramine, protopine, mecambridine, nudaurine, cryptopine and papaverrubines B, D, and G.In the fraction of quaternary bases the presence of traces of coptisine was detected, and in addition to alborine (alkaloid PO-5) cis-N-methyltetrahydropalmatinium hydroxide (V) was isolated for the first time in the form of iodide from P. kerneri.In P. tatricum (NYAR.) EHREND. allocryptopine, epialpinine, and amurensinine were identified as the dominant alkaloids, while among the minor components protopine, amurensine, muramine, palmatine, coptisine, corytuberine (IIIb), N-methyltetrahydropalmatinium hydroxide, and N-methylamurensinium hydroxide could be demonstrated.Corydine (IIIa) and corytuberine (IIIb) represent the first two aporphine alkaloids found in the Scapiflora section.

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METHOD OF CAPTURING AND STABILISING THIOLS

The present invention relates to a method of capturing and stabilising volatile thiol malodour generated on the human skin, comprising steps of: i) contacting the human skin with a substrate, ii) absorbing said thiol into the substrate, and iii) reacting said thiol with a thiol-capture agent. The invention also relates to a method of quantifying said thiol, a method of assessing the deodorizing performance of a cosmetic composition on the human skin.

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Brief introduction of 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione

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Theoretical and experimental NMR study of protopine hydrochloride isomers

The 1H and 13C NMR chemical shifts of cis- and trans-protopinium salts were measured and calculated. The calculations of the chemical shifts consisted of conformational analysis, geometry optimization (RHF/6-31G** method) and shielding constants calculations (B3LYP/6-31G** method). Based on the results of the quantum chemical calculations, two sets of experimental chemical shifts were assigned to the particular isomers. According to the experimental results, the trans-isomer is more stable and its population is ?68%. Copyright

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Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity

Chemical investigation of the tubers of Corydalis ternata resulted in the isolation and characterization of four new benzylisoquinoline alkaloids, epi-coryximine (1) and coryternatines A-C (2-4), along with 10 known alkaloids (5-14). Their structures were established on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. In addition, the cytotoxicities of the alkaloids (1-14) were evaluated by determining their inhibitory effects on several human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) using the SRB assay. Compound 8 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (IC50 = 8.34, 5.14, 7.87, and 2.86 muM, respectively). The four new compounds (1-4) exhibited selective cytotoxicity against the HCT-15 cell line.

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Final Thoughts on Chemistry for 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid

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Synergistic role of graphene oxide-magnetite nanofillers contribution on ionic conductivity and permeability for polybenzimidazole membrane electrolytes

Efficient nanofillers within polymeric electrolytes are an interesting design for constructing high-performance membranes for direct methanol alkaline fuel cells. In this work magnetite (Fe3O4) particles are synthesized onto graphene oxide (GO) nanofillers and incorporating into a polybenzimidazole (PBI) matrix for membrane formation. The Fe3O4 nanoparticles are simultaneously anchored onto GO carbon basal planes to form GO-Fe3O4 via the solvothermal process. The pristine PBI, PBI/GO, PBI/Fe3O4, and PBI/GO-Fe3O4 composites are formulated and doped with potassium hydroxide solution to form ionic conductors. GO nanofillers suppress the methanol permeation rate in PBI/GO-Fe3O4 composite membranes while the anchored Fe3O4 nanoparticles result in a bumpy surface, reducing chain packing and promoting anionic conductivity via the loose polymeric free volume. Therefore, the conductivity-to-permeability selectivity of PBI/GO-Fe3O4 composite membrane is improved three times than other samples. The maximum peak power density (Pmax) of a fuel cell employing the PBI/GO-Fe3O4 composite membrane achieves 233 mW cm?2 at 80 C. The superior power output is attributed to the combined effect of the enhanced anionic conduction resulting from anchored GO-Fe3O4 particles’ steric hindrance on polymer chains to enlarged ion diffusion pathways, and the reduced methanol cross-over from the GO’s high aspect ratio to retard molecular permeation in the composite membrane.

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