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Related Products of 1122-10-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1122-10-7, molcular formula is C4HBr2NO2, introducing its new discovery.

Total syntheses of the slime mold alkaloid arcyriacyanin A

Arcyriacyanin A (1) has been synthesized by three different routes. In the first synthesis the bisbromomagnesium salt of 2,4′-biindole (5) was treated with dibromomaleimide (6) to yield arcyriacyanin A (1). The second approach used an intramolecular Hock reaction for the cyclization of a 4-(triflyloxy)arcyriarubin 8 to N-methylarcyriacyanin A (2). Thirdly, compound 2 was obtained by a domino Heck reaction between 3-bromo-4-[1(tert-butoxycarbonyl)indol-3-yl]-1-methylmaleimide (9) and 4-bromoindole (10). The N-methyl derivative 2 could be transformed into arcyriacyanin A (1) by standard methods.

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Reference of 17057-04-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 17057-04-4, Name is 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,introducing its new discovery.

Thermally cleavable surfactants

Two new surfactant molecules are reported which contain thermally labile Diels-Alder adducts connecting the polar and non-polar sections of each molecule. The two surfactants possess identical non-polar dodecyl tail segments but exhibit different polar headgroups. The surfactants become soluble in water when anionic salts are formed through the deprotonation of the surfactant headgroups by the addition of potassium hydroxide. When either surfactant is exposed to temperature above about 60 C., the retro Diels-Alder reaction occurs, yielding hydrophilic and hydrophobic fragments and the aqueous solutions of the surfactants subsequently exhibit loss of all surface-active behavior.

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One new alkaloid from Chelidonium majus L

One new alkaloid, together with 10 known compounds were isolated from the aerial parts of Chelidonium majus L. by repeated silica gel column chromatography. Their chemical structures were elucidated on the basis of physicochemical and spectroscopic data. Among them, 6-acetonyldihydrochelerythrine (4), 6-acetonyldihydrosanguinarine (5), 6-ketenesanguinarine (6), demethylchelerythrine (7) and demethylsanguinarine (11) were isolated for the first time from this plant. Compound 6 was identified as a new compound. These compounds were screened for cytotoxicity against human non-small lung carcinoma (H1299), breast cancer (MCF-7) and liver cancer (SMMC-7721). In a series of cytotoxic tests, compounds 9 and 10 displayed potent cytotoxic activity against H1299, MCF-7 and SMMC-7721, with the IC50values of 8.16-35.25 mug/mL.

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Extracurricular laboratory:new discovery of 3,4-Dibromo-1H-pyrrole-2,5-dione

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Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues

The construction of the ring-expanded carbazole system, forming arcyriaflavin homologues, is efficiently accomplished by the reaction of 2,2?-bridged bis-indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione derivatives under Grignard conditions. A ring size of up to nine members in the central ring is achievable. Substitutions either at the indole system or at the imide-N are also possible. The conformation of homoarcyriaflavins as a cross-link between the rigid arcyriaflavins and the flexible arcyriarubins was investigated by NMR, X-ray, and semiempiric quantum chemical calculation methods.

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Chemically-Locked Bispecific Antibodies

There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together with bio-orthogonal click chemistry.

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Top Picks: new discover of 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione

If you are interested in 1081-17-0, you can contact me at any time and look forward to more communication. Formula: C11H9NO3

Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C11H9NO3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1081-17-0

Bioactive isoquinoline alkaloids from Glaucium arabicum

Phytochemical investigation of the aerial parts of Glaucium arabicum Fresen. (Papaveraceae) led to the isolation of two previously undescribed isoquinoline alkaloids araglaucine A, and araglaucine B, together with seven known ones 1-[(3?,4?-dimethoxy-2?-methylcarboxy)benzoyl]-6,7-methylenedioxy isoquinoline (araglaucine C), (7R,14S)-trans-N-methylcanadinium nitrate, (R,S)-trans-N-methylstylopine, 14-hydroxy-N-methyl canadine, 14-hydroxy-N-methyl stylopine, protopine, norsanguinarine, as well as beta-sitosterol, and beta-sitosterol 3-O-beta?D-glucoside. Their structural elucidation was based on the measurements of 1D, 2D NMR, HRESIMS, UV, IR and X-ray crystallography. The compounds were evaluated for their anti-melanogenesis activity using B16 melanoma cell lines. Compound (7R,14S)-trans-N-methylcanadinium nitrate exhibited a promising melanin synthesis inhibitory activity (?35%) at concentration 5 mug/ml (12.01 muM) with low cytotoxicity (?12%).

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Reference of 28537-70-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 28537-70-4, Name is 1,1′-(Butane-1,4-diyl)bis(1H-pyrrole-2,5-dione),introducing its new discovery.

Two cantharides imide dimer derivative crystal structure, preparation method and use (by machine translation)

The invention relates to two cantharides imide dimer derivative crystal structure, preparation method and some nature. The appearance of the two crystals are colorless rod-like crystal: 1st crystal melting point 165.0? 166.0 C, molecular formula C 20 H 20 N 2 O 6, chemical known as the: 2,2 ?? (Butane? 1,4? Diyl) b (3a, 4, 7, 7a? Tetrahydrofurfuroxy? 4,7? Epoxy? 1,3? Dihydroisoquinoline indol? 1,3? Diketone), the crystallization is a monoclinic system, P2 1 / C Space group, a= 11.362 (3)? , B= 5.8986 (17)? , C= 13.186 (4)? , Alpha =gamma= 90 , beta = 98.318 (4) , V= 874.4 (4)? 3, Z= 2 ; crystal melting point of the 2nd 158.8? 159.4 C, molecular formula C 22 H 24 N 2 O 6, chemical known as the: 2,2 ?? (Hexane? 1,6? Diyl) b (3a, 4, 7, 7a? Tetrahydrofurfuroxy? 4,7? Epoxy? 1,3? Dihydroisoquinoline indol? 1,3? Diketone), the crystallization is a monoclinic system, P 2 1 / n Space group, a= 5.246 (3)? , B= 28.643 (17)? , C= 6.546 (4)? , Alpha =gamma= 90 , beta = 94.401 (10) , V= 980.8 (10)? 3, Z= 2. The two dimer derivative crystal preparation method is simple, the lung cancer cells, colon cancer cells breast cancer cells with mild and the inhibiting effect of the. (by machine translation)

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Protopine hydrochloride

Protopine hydrochloride (5,6,14,14a-tetrahydro-14a-hydroxy-7 -methyl-8H-bis[1,3] benzodioxolo [5,6-a:4,5-g]quinolizinium chloride, C20H20 NO5 +¡¤Cl-) is the salt of the isoquinoline alkaloid protopine. It is formed by the action of dilute hydrochloric acid on the protopine free base. The N-methyl and hydroxyl groups are in a trans configuration in the quinolizine ring and the central quinolizine N-C bond is unusually long [1.579 (2) A]. The crystal is a racemate.

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Comparison of anticancer activity and hplc-dad determination of selected isoquinoline alkaloids from thalictrum foetidum, berberis sp. And chelidonium majus extracts

Background: Plants are an important origin of natural substances that The raw material for various pharmaceutical and therapeutic applications due to The presence of phytochemicals, such as alkaloids. Alkaloids, which are found in different plant species, possess numerous biological activities. Some alkaloids have strong cytotoxic effects on various cancer cells. The search for new drugs to treat various cancers is one of The most important challenges of modern scientific research. Objective: This study aimed to investigate of cytotoxic activity of extracts that were obtained from Chelidonium Majus; Berberis sp.; Thalictrum foetidum containing various alkaloids on selected cancer cell lines. The aim was also The quantification of selected alkaloids in The investigated extracts by HPLC. Methods: The analysis of alkaloids contents were performed while using HPLC in reversed phase (RP) mode using Polar RP column and mobile phase containing acetonitrile, water, and ionic liquid. The cytotoxic effect of The tested plant extracts and respective alkaloids’ standards were examined while using human pharyngeal squamous carcinoma cells (FaDu), human tongue squamous carcinoma cells (SCC-25), human breast adenocarcinoma cell line (MCF-7), and human triple-negative breast adenocarcinoma cell line (MDA-MB-231). Conclusion: All of The investigated plant extracts possess cytotoxic activity against cancer cell lines: FaDu, SCC-25, MCF-7, and MDA-MB-231. The highest cytotoxic activity against FaDu and MDA-MB-231 cells was observed for Chelidonium majus root extract, while the highest cytotoxic activity against SCC-25 and MCF-7 cells was estimated for The Thalictrum foetidum root extract. There obtained significant differences in The cytotoxic activity of extracts that were obtained from The roots and herbs of Chelidonium majus and Thalictrum foetidum. Based on these results, investigated plant extracts can be recommended for further investigations of anticancer activity.

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New anti-Alzheimer drugs from biodiversity: The role of the natural acetylcholinesterase inhibitors

Alzheimer’s disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays, drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD, and natural products have played an important alternative role in the research for new acetylcholinesterase inhibitors, as exemplified through the discovery of galantamine. This profile conducts us to give in this paper an overview relating the several classes of natural products with anti-cholinesterasic activity as potential templates to the design of new selective and powerful anti-Alzheimer drugs.

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